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Table 2 Correlation analysis between levels of A11 immunoreactivity and odor-induced Ca2+ activity at the angle-matched olfactory synapse

From: Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice

Parameter Group A L A E Group B G AP HA H
Number of XY pairs 180 180 180 180 180 180 180 180 180
Spearman’s rho 0.5951 0.3453 0.5132 0.4722 − 0.4434 − 0.1664 − 0.2983 − 0.4641 − 0.5803
95% confidence interval − 0.6849 to − 0.4897 − 0.4710 to − 0.2058 − 0.6159 to − 0.3934 − 0.5811 to − 0.3466 0.3141 to 0.5565 0.01672 to 0.3809 0.1551 to 0.4292 0.3375 to 0.5743 0.4713 to 0.6719
P value (two-tailed) < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 0.0251 < 0.0001 < 0.0001 < 0.0001
P value summary *** *** *** *** *** * *** *** ***
Exact or approximate P value? Gaussian approximation Gaussian approximation Gaussian approximation Gaussian approximation Gaussian approximation Gaussian approximation Gaussian approximation Gaussian approximation Gaussian approximation
Is the correlation significant? (alpha = 0.05) Yes Yes Yes Yes Yes Yes Yes Yes Yes
  1. Data represent the relationship between A11 immunoreactivity and odor-induced Ca2+ activity at the angle-matched olfactory synapse (Fig. S4). The experimental odorants included lyral [L], eugenol [E], acetophenone [A], geraniol [G], ally phenylacetate [AP], heptanoic acid [HA], and heptanal [H]. For the statistical analysis, a non-parametric Spearman’s correlation was performed, followed by linear regression with a 95% confidence interval. Statistical significances are denoted as follows: non-significant (ns); *P < 0.05; ***P < 0.001