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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice

Fig. 1

Atypical, AD-like olfactory behavior in 5xFAD transgenic mice. Experimental subjects are 3-month WT or 5xFAD mice unless otherwise noted. a, b Food seeking test (WT, n = 6; 5xFAD, n = 6). a Scheme illustration. b The latency was measured as mean ± SEM. For statistical analysis, an unpaired t test was performed. ce Odor detection test was performed (WT, n = 6; 5xFAD, n = 6). c Scheme illustration. For PI analysis, areas a and b were defined to distinguish the location of the experimental odorant in the cage. d The PI value is represented as mean ± SEM. The experimental odorants refer to lyral [L], eugenol [E], acetophenone [A], geraniol [G], ally phenylacetate [AP], heptanoic acid [HA], and heptanal [H]. For statistical analysis, an unpaired t test was performed. e Representative heat map showing duration (H; high, L; low). Statistical significances are denoted as follows: ns, non-significant; *P <  0.05, **P <  0.01, ***P <  0.001). Wild-type (WT), five familial AD mutations (5xFAD), Alzheimer’s disease (AD)

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