Fig. 1From: Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD miceAtypical, AD-like olfactory behavior in 5xFAD transgenic mice. Experimental subjects are 3-month WT or 5xFAD mice unless otherwise noted. a, b Food seeking test (WT, n = 6; 5xFAD, n = 6). a Scheme illustration. b The latency was measured as mean ± SEM. For statistical analysis, an unpaired t test was performed. c–e Odor detection test was performed (WT, n = 6; 5xFAD, n = 6). c Scheme illustration. For PI analysis, areas a and b were defined to distinguish the location of the experimental odorant in the cage. d The PI value is represented as mean ± SEM. The experimental odorants refer to lyral [L], eugenol [E], acetophenone [A], geraniol [G], ally phenylacetate [AP], heptanoic acid [HA], and heptanal [H]. For statistical analysis, an unpaired t test was performed. e Representative heat map showing duration (H; high, L; low). Statistical significances are denoted as follows: ns, non-significant; *P < 0.05, **P < 0.01, ***P < 0.001). Wild-type (WT), five familial AD mutations (5xFAD), Alzheimer’s disease (AD)Back to article page