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Table 3 Optimal plasma biomarker cut-offs with corresponding performance parameters for detecting amyloid-PET positivity

From: Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis

Plasma ratio

Platform

Group

Cut-off

Sensitivity, %

Specificity, %

PPV, %

NPV, %

Age, APOE-ε4

 

Total

na

84 (69–94)

46 (38–54)

27 (23–31)

93 (85–96)

CN

na

67 (45–84)

65 (56–73)

25 (19–33)

92 (86–95)

aMCI

na

79 (49–95)

67 (45–84)

58 (43–72)

84 (65–94)

1–42/Aβ1–40

ELISA

Total

< 0.159

78 (62–90)

75 (68–82)

42 (34–50)

93 (88–96)

CN

< 0.159

78 (56–93)

81 (74–87)

41 (32–51)

96 (91–98)

aMCI

< 0.170

86 (57–98)

67 (45–84)

60 (45–73)

89 (68–97)

SIMOA

Total

< 0.230

74 (57–87)

80 (72–86)

46 (37–55)

93 (88–96)

CN

< 0.229

70 (47–87)

79 (71–86)

36 (27–46)

94 (89–97)

aMCI

< 0.226

79 (49–95)

88 (68–97)

79 (55–92)

88 (71–95)

1–42/t-tau

ELISA

Total

< 1.19

84 (68–94)

64 (56–71)

35 (30–41)

95 (89–97)

CN

< 1.12

78 (56–93)

69 (60–76)

30 (23–37)

96 (90–98)

aMCI

< 1.18

93 (66–100)

79 (58–93)

72 (54–85)

95 (74–99)

SIMOA

Total

< 0.862

79 (63–90)

68 (60–75)

36 (30–43)

93 (88–96)

CN

< 0.899

83 (61–95)

63 (54–71)

27 (22–33)

96 (90–99)

aMCI

< 0.815

79 (49–95)

88 (68–97)

79 (55–92)

88 (71–95)

  1. aMCI amnestic mild cognitive impairment, β-amyloid, CN cognitively normal, NPV negative predictive value, PPV positive predictive value, t-tau total tau