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Table 3 Optimal plasma biomarker cut-offs with corresponding performance parameters for detecting amyloid-PET positivity

From: Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis

Plasma ratio Platform Group Cut-off Sensitivity, % Specificity, % PPV, % NPV, %
Age, APOE-ε4   Total na 84 (69–94) 46 (38–54) 27 (23–31) 93 (85–96)
CN na 67 (45–84) 65 (56–73) 25 (19–33) 92 (86–95)
aMCI na 79 (49–95) 67 (45–84) 58 (43–72) 84 (65–94)
1–42/Aβ1–40 ELISA Total < 0.159 78 (62–90) 75 (68–82) 42 (34–50) 93 (88–96)
CN < 0.159 78 (56–93) 81 (74–87) 41 (32–51) 96 (91–98)
aMCI < 0.170 86 (57–98) 67 (45–84) 60 (45–73) 89 (68–97)
SIMOA Total < 0.230 74 (57–87) 80 (72–86) 46 (37–55) 93 (88–96)
CN < 0.229 70 (47–87) 79 (71–86) 36 (27–46) 94 (89–97)
aMCI < 0.226 79 (49–95) 88 (68–97) 79 (55–92) 88 (71–95)
1–42/t-tau ELISA Total < 1.19 84 (68–94) 64 (56–71) 35 (30–41) 95 (89–97)
CN < 1.12 78 (56–93) 69 (60–76) 30 (23–37) 96 (90–98)
aMCI < 1.18 93 (66–100) 79 (58–93) 72 (54–85) 95 (74–99)
SIMOA Total < 0.862 79 (63–90) 68 (60–75) 36 (30–43) 93 (88–96)
CN < 0.899 83 (61–95) 63 (54–71) 27 (22–33) 96 (90–99)
aMCI < 0.815 79 (49–95) 88 (68–97) 79 (55–92) 88 (71–95)
  1. aMCI amnestic mild cognitive impairment, β-amyloid, CN cognitively normal, NPV negative predictive value, PPV positive predictive value, t-tau total tau