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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis

Fig. 2

Correlations of ELISA and SIMOA plasma Aβ1–42/Aβ1–40 and Aβ1–42/t-tau with established PET- and CSF-based AD biomarkers. Plasma Aβ1–42/Aβ1–40 (ad) and Aβ1–42/t-tau (eh) with ELISA (left, blue) and SIMOA (right, orange) Aβ measurements were plotted against amyloid-PET binding (i.e. Centiloid values) (n = 199: 161 CN controls and 38 aMCI patients) and CSF Aβ1–42/t-tau (n = 56: 37 CN controls and 19 aMCI patients). Filled circles represent measurements in CN controls, and open circles represent measurements in aMCI patients. Spearman rank correlations were calculated for the entire study population as well as for the CN and aMCI subgroups. p values are indicated in bold when significant after correction for multiple comparisons (significance level α = 0.05/2 = 0.03). aMCI, amnestic mild cognitive impairment; Aβ, β-amyloid; CN, cognitively normal; ELISA, enzyme-linked immunosorbent assay; SIMOA, single molecule array; t-tau, total tau

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