Fig. 6

α-Syn immunoreactivity in dementia with Lewy bodies. Representative images and corresponding quantification of α-Syn immunoreactivity obtained using IGG-1, IGG-2, IGG-3 and NOV. α-Syn-positive inclusions were detected with both NOV and all 3 antibodies in each brain region. IGG-1, IGG-2 and IGG-3 detected a significantly higher quantity of α-Syn inclusions than NOV in all brain regions (except IGG-1 in substantia nigra) (P < 0.05). IGG-2 and IGG-3 detected a significantly higher quantity than IGG-1 in all brain regions except the cortical GM and internal capsule (P < 0.05). α-Syn detected by IGG-3 was significantly higher than IGG-2 in the substantia nigra, putamen and temporal cortex (P > 0.0001). Error bars show mean ± 95% CI. Scale bar = 100 μm