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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy

Fig. 3

α-Syn immunoreactivity in multiple system atrophy. Representative images and corresponding quantification of α-Syn immunoreactivity obtained using IGG-1, IGG-2, IGG-3 and NOV. α-Syn-positive inclusions were detected with both NOV and all 3 antibodies in each brain region. IGG-1, IGG-2 and IGG-3 detected significantly a higher quantity of α-Syn inclusions than NOV in the substantia nigra and temporal lobe GM and WM (P < 0.05). IGG-2 and IGG-3 detected a significantly higher quantity than NOV and IGG-1 in all brain regions (P < 0.05). α-Syn detected by IGG-3 was significantly higher than IGG-2 in the substantia nigra and temporal lobe GM and WM (P > 0.0001). Error bars show mean ± 95% CI. Scale bar = 100 μm

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