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Table 2 Association between AMY1 copy number and Alzheimer’s dementia during 20 years of follow-up

From: Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer’s dementia

 

Alzheimer’s dementia HR (95% CI)

AMY1 copy number

Unadjusted

Age-adjusted

Fully adjusted1

Per 1 increase

0.98 (0.93, 1.03)

0.98 (0.93, 1.03)

0.97 (0.92, 1.02)

By four groups

 1–5

0.74 (0.53, 1.02)

0.75 (0.54, 1.04)

0.75 (0.54, 1.05)

 6 (reference)

1

1

1

 7–9

0.93 (0.67, 1.27)

0.92 (0.67, 1.27)

0.86 (0.62, 1.20)

 ≥ 10

0.62 (0.41, 0.94)*

0.62 (0.41, 0.95)*

0.59 (0.38, 0.90)*

n events/total

247/5422

247/5422

235/5028

  1. Cox proportional hazards of Alzheimer’s dementia by number of copies of the AMY1 gene
  2. Data is presented as HR (95% CI) 1 adjusted for age, sex, education, APOE ε4, body mass index, and diabetes at baseline. n represents number of events (cases with AD) and total number of individuals included in the model
  3. *p value < 0.05
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Alzheimer's Research & Therapy

ISSN: 1758-9193