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Table 2 Association between AMY1 copy number and Alzheimer’s dementia during 20 years of follow-up

From: Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer’s dementia

  Alzheimer’s dementia HR (95% CI)
AMY1 copy number Unadjusted Age-adjusted Fully adjusted1
Per 1 increase 0.98 (0.93, 1.03) 0.98 (0.93, 1.03) 0.97 (0.92, 1.02)
By four groups
1–5 0.74 (0.53, 1.02) 0.75 (0.54, 1.04) 0.75 (0.54, 1.05)
6 (reference) 1 1 1
7–9 0.93 (0.67, 1.27) 0.92 (0.67, 1.27) 0.86 (0.62, 1.20)
≥ 10 0.62 (0.41, 0.94)* 0.62 (0.41, 0.95)* 0.59 (0.38, 0.90)*
n events/total 247/5422 247/5422 235/5028
  1. Cox proportional hazards of Alzheimer’s dementia by number of copies of the AMY1 gene
  2. Data is presented as HR (95% CI) 1 adjusted for age, sex, education, APOE ε4, body mass index, and diabetes at baseline. n represents number of events (cases with AD) and total number of individuals included in the model
  3. *p value < 0.05