| |
Alzheimer’s dementia HR (95% CI)
|
|---|
|
AMY1 copy number
|
Unadjusted
|
Age-adjusted
|
Fully adjusted1
|
|---|
|
Per 1 increase
|
0.98 (0.93, 1.03)
|
0.98 (0.93, 1.03)
|
0.97 (0.92, 1.02)
|
|
By four groups
|
|
1–5
|
0.74 (0.53, 1.02)
|
0.75 (0.54, 1.04)
|
0.75 (0.54, 1.05)
|
|
6 (reference)
|
1
|
1
|
1
|
|
7–9
|
0.93 (0.67, 1.27)
|
0.92 (0.67, 1.27)
|
0.86 (0.62, 1.20)
|
|
≥ 10
|
0.62 (0.41, 0.94)*
|
0.62 (0.41, 0.95)*
|
0.59 (0.38, 0.90)*
|
|
n events/total
|
247/5422
|
247/5422
|
235/5028
|
- Cox proportional hazards of Alzheimer’s dementia by number of copies of the AMY1 gene
- Data is presented as HR (95% CI) 1 adjusted for age, sex, education, APOE ε4, body mass index, and diabetes at baseline. n represents number of events (cases with AD) and total number of individuals included in the model
- *p value < 0.05
