Table 1 Descriptive statistics of the study cohort stratified in four groups by numbers of α-amylase copies
Alzheimer’s dementia (n = 247) | ||||
|---|---|---|---|---|
AMY1 copy number | ||||
Baseline characteristics | 1–5 (n = 64, 26%) | 6 (n = 86, 35%) | 7–9 (n = 67, 27%) | ≥ 10 (n = 30, 12%) |
Age, years | 61.6 (4.2) | 61.6 (4.6) | 61.3 (4.9) | 62.4 (3.6) |
Women | 42 (66%) | 64 (74%) | 41 (61%) | 19 (63%) |
APOE ε4 carrier | 31 (48%) | 59 (70%) | 40 (61%) | 18 (60%) |
Education: | ||||
Primary/elementary school (≤ 8 years) | 31 (51%) | 39 (46%) | 32 (50%) | 14 (50%) |
Body mass index | 26.4 (4.7) | 25.3 (3.9) | 26.3 (3.5) | 26.8 (4.2) |
Fasting blood glucose, mmol/L | 5.2 (1.3) | 5.2 (1.5) | 5.3 (1.2) | 5.0 (0.6) |
Diabetes at baseline | 3 (4%) | 5 (6%) | 10 (15%) | 1 (3%) |
Diabetes, prevalent or incident | 11 (17%) | 14 (17%) | 20 (30%) | 5 (17%) |
Individuals without Alzheimer’s dementia (n = 5175) | ||||
AMY1 copy number | ||||
Baseline characteristics | 1–5 (n = 1525, 30%) | 6 (n = 1503, 29%) | 7–9 (n = 1289, 25%) | ≥ 10 (n = 858, 16%) |
Age, years | 57.2 (5.9) | 57.3 (5.9) | 57.3 (5.9) | 57.1 (6.0) |
Women | 868 (57%) | 887 (59%) | 727 (56%) | 508 (59%) |
APOE ε4 carrier | 428 (29%) | 415 (28%) | 359 (28%) | 269 (32%) |
Education | ||||
Primary/elementary school (≤ 8 years) | 670 (47%) | 634 (45%) | 577 (48%) | 357 (44%) |
Body mass index | 25.6 (3.9) | 25.9 (4.1) | 25.7 (3.9) | 25.8 (4.1) |
Fasting blood glucose, mmol/L | 5.2 (1.5) | 5.2 (1.5) | 5.1 (1.2) | 5.2 (1.5) |
Diabetes at baseline | 78 (5%) | 79 (5%) | 55 (4%) | 36 (4%) |
Diabetes, prevalent or incident | 340 (22%) | 334 (23%) | 254 (20%) | 178 (21%) |