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Table 1 Descriptive statistics of the study cohort stratified in four groups by numbers of α-amylase copies

From: Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer’s dementia

  Alzheimer’s dementia (n = 247)
AMY1 copy number
Baseline characteristics 1–5 (n = 64, 26%) 6 (n = 86, 35%) 7–9 (n = 67, 27%) ≥ 10 (n = 30, 12%)
Age, years 61.6 (4.2) 61.6 (4.6) 61.3 (4.9) 62.4 (3.6)
Women 42 (66%) 64 (74%) 41 (61%) 19 (63%)
APOE ε4 carrier 31 (48%) 59 (70%) 40 (61%) 18 (60%)
Education:
  Primary/elementary school (≤ 8 years) 31 (51%) 39 (46%) 32 (50%) 14 (50%)
Body mass index 26.4 (4.7) 25.3 (3.9) 26.3 (3.5) 26.8 (4.2)
Fasting blood glucose, mmol/L 5.2 (1.3) 5.2 (1.5) 5.3 (1.2) 5.0 (0.6)
Diabetes at baseline 3 (4%) 5 (6%) 10 (15%) 1 (3%)
Diabetes, prevalent or incident 11 (17%) 14 (17%) 20 (30%) 5 (17%)
  Individuals without Alzheimer’s dementia (n = 5175)
AMY1 copy number
Baseline characteristics 1–5 (n = 1525, 30%) 6 (n = 1503, 29%) 7–9 (n = 1289, 25%) ≥ 10 (n = 858, 16%)
Age, years 57.2 (5.9) 57.3 (5.9) 57.3 (5.9) 57.1 (6.0)
Women 868 (57%) 887 (59%) 727 (56%) 508 (59%)
APOE ε4 carrier 428 (29%) 415 (28%) 359 (28%) 269 (32%)
Education
  Primary/elementary school (≤ 8 years) 670 (47%) 634 (45%) 577 (48%) 357 (44%)
Body mass index 25.6 (3.9) 25.9 (4.1) 25.7 (3.9) 25.8 (4.1)
Fasting blood glucose, mmol/L 5.2 (1.5) 5.2 (1.5) 5.1 (1.2) 5.2 (1.5)
Diabetes at baseline 78 (5%) 79 (5%) 55 (4%) 36 (4%)
Diabetes, prevalent or incident 340 (22%) 334 (23%) 254 (20%) 178 (21%)
  1. Data is presented as mean (SD) or n (%). Missing data APOE (n = 90), education (n = 300), BMI (n = 7), and glucose (n = 544)