|
Baseline characteristics
|
1–5 (n = 64, 26%)
|
6 (n = 86, 35%)
|
7–9 (n = 67, 27%)
|
≥ 10 (n = 30, 12%)
|
|
Age, years
|
61.6 (4.2)
|
61.6 (4.6)
|
61.3 (4.9)
|
62.4 (3.6)
|
|
Women
|
42 (66%)
|
64 (74%)
|
41 (61%)
|
19 (63%)
|
|
APOE ε4 carrier
|
31 (48%)
|
59 (70%)
|
40 (61%)
|
18 (60%)
|
|
Education:
|
|
Primary/elementary school (≤ 8 years)
|
31 (51%)
|
39 (46%)
|
32 (50%)
|
14 (50%)
|
|
Body mass index
|
26.4 (4.7)
|
25.3 (3.9)
|
26.3 (3.5)
|
26.8 (4.2)
|
|
Fasting blood glucose, mmol/L
|
5.2 (1.3)
|
5.2 (1.5)
|
5.3 (1.2)
|
5.0 (0.6)
|
|
Diabetes at baseline
|
3 (4%)
|
5 (6%)
|
10 (15%)
|
1 (3%)
|
|
Diabetes, prevalent or incident
|
11 (17%)
|
14 (17%)
|
20 (30%)
|
5 (17%)
|
| |
Individuals without Alzheimer’s dementia (n = 5175)
|
|
AMY1 copy number
|
|
Baseline characteristics
|
1–5 (n = 1525, 30%)
|
6 (n = 1503, 29%)
|
7–9 (n = 1289, 25%)
|
≥ 10 (n = 858, 16%)
|
|
Age, years
|
57.2 (5.9)
|
57.3 (5.9)
|
57.3 (5.9)
|
57.1 (6.0)
|
|
Women
|
868 (57%)
|
887 (59%)
|
727 (56%)
|
508 (59%)
|
|
APOE ε4 carrier
|
428 (29%)
|
415 (28%)
|
359 (28%)
|
269 (32%)
|
|
Education
|
|
Primary/elementary school (≤ 8 years)
|
670 (47%)
|
634 (45%)
|
577 (48%)
|
357 (44%)
|
|
Body mass index
|
25.6 (3.9)
|
25.9 (4.1)
|
25.7 (3.9)
|
25.8 (4.1)
|
|
Fasting blood glucose, mmol/L
|
5.2 (1.5)
|
5.2 (1.5)
|
5.1 (1.2)
|
5.2 (1.5)
|
|
Diabetes at baseline
|
78 (5%)
|
79 (5%)
|
55 (4%)
|
36 (4%)
|
|
Diabetes, prevalent or incident
|
340 (22%)
|
334 (23%)
|
254 (20%)
|
178 (21%)
|
