Fig. 3

AMY1A copy number variation, alpha (α)-amylase activity and gene expression in post-mortem hippocampal tissue. Scatter plot in a shows a trend to correlation between AMY1A CNV and α-amylase activity (optical density (ΔOD) at 405 nm during 30 min) in the Alzheimer’s dementia (AD) group (orange) and a non-significant correlation in total cohort (dotted line) or non-demented control (NC) group (black). Scatter plot in b shows a significant correlation between AMY1A CNV and relative α-amylase expression normalized against values of housekeeping genes ribosomal protein L13A (RPL13A) and hydroxymethylbilane synthase (HMBS) in the AD group (orange), but no correlation was seen in the whole cohort or NC group (black). Column scatter plot in c showing α-amylase activity in AD patients (orange) and NC where median α-amylase activity in females is significantly higher compared to males. Data was analyzed using the Spearman (a and b) and Mann-Whitney U test (c) and presented as median and range (c). ***P < 0.001