Fig. 4
From: Genetic associations of in vivo pathology influence Alzheimer’s disease susceptibility
Genes with rare variants that are significantly associated with in vivo AD pathologies. Observed rare functional variants in the case or control groups defined by each clinical parameter are shown for each gene. a LPL with Aβ deposition in the global brain regions. b DSG2 with AD-signature cortical thickness. c ITPR1 with hippocampal volume. The right panel displays the exploratory voxel-based analyses of brain imaging to demonstrate the regional pattern differences in AD imaging biomarker phenotype between carriers and non-carriers