Investigating the clinico-anatomical dissociation in the behavioral variant of Alzheimer disease

Table 1 Participant characteristics

	bvAD	tAD	bvFTD	CN₁	p value
n	29	28	28	34
Age, years	64.4 (9.4)	63.0 (9.3)	64.6 (4.4)	64.9 (9.9)	0.84
Sex, no. male (%)	17 (59)	16 (55)	21 (70)	22 (65)	0.82
Education^a, years mean (SD)	15.7 (2.6)	15.8 (2.8)	15.1 (3.4)	17.9 (2.0)	0.001
MMSE^{b †}, mean (SD)	22.0 (5.9)	22.1 (5.7)	21.3 (6.7)	29.5 (0.7)	0.001
APOEε4 positivity^c, no. of patients (%)	11/18 (61)	10/14 (67)	3/27 (11)	6/34 (18)	< 0.001
MRI scanner field strength					0.16
1.5 T	17 (59)	22 (79)	14 (50)	22 (65)
3 T	12 (41)	6 (21)	14 (50)	12 (35)
Memory domain z-score^d °, mean (SD)	− 3.5 (1.5)	− 3.9 (1.3)	− 2.8 (1.7)	0.3 (0.9)	< 0.001
Executive domain z-score^e °, mean (SD)	− 1.9 (1.0)	− 1.9 (1.0)	− 2.1 (1.0)	0.0 (0.6)	< 0.001
NPI score^{f ◊}, mean (SD)	30.2 (20.6)	12.8 (15.4)	34.7 (17.2)	–	0.001

Differences between groups were assessed using (M)ANOVA tests, chi-square tests, and Kruskall-Wallis tests with post hoc Mann-Whitney U tests, where appropriate. All p values were corrected for multiple comparisons using Bonferroni correction. Data presented above are based on the groups for whom T1 MRI scans were available. See Supplement 2 for equivalent information in groups for which FDG and FLAIR-MRI scans were available
^†MMSE data was available for n = 26 for bvAD, n = 19 for tAD, n = 27 for bvFTD, and n = 34 for CN₁
°Cognition data was available for n = 22 for bvAD, n = 28 for tAD, n = 24 for bvFTD, and n = 30 for CN₁
^◊NPI data was available for n = 13 for bvAD, n = 18 for tAD, n = 20 for bvFTD, and n = 0 for CN₁
^aControls > patients, p < 0.01
^bControls > patients, p < 0.001
^cbvAD and tAD > controls, p < 0.01, bvAD and tAD > bvFTD, p < 0.001
^dControls > patients, p < 0.001, tAD < bvFTD, p < 0.05
^eControls > patients, p < 0.001
^fbvAD and bvFTD > tAD, p < 0.01

ISSN: 1758-9193