Fig. 3

Subcortical gray matter volumes and regional white matter hyperintensity volumes across diagnostic groups. a Subcortical gray matter volumes, displayed in cm³. Error bars indicate standard deviations. *p < 0.05, **p < 0.001, Bonferroni corrected (black indicating patient contrasts, while gray represents patient vs. control contrasts). Green structures in the MRI template indicate the caudate nucleus, dark blue structures indicate the putamen, red structures indicate the globus pallidus, yellow indicate the thalamus, and light blue structures indicate the amygdala. b Regional white matter hyperintensity volumes. In this plot, the angular sections correspond to different lobes while the concentric rings represent equidistant layers of white matter. Radius increases with the distance to the ventricles (center layer: periventricular – outer layer: juxtacortical). Grayed-out regions indicate regions where the difference when compared to the control group did not reach significance. Colored regions from light yellow to red indicate the multiplicative factor when compared to control group after correction for sex, scanner field strength, and total intracranial volume