Table 9 T-tau and p-tau subgroup comparison on tau PET uptake
From: Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts
T-tau subgroup effect | T-tau subgroup estimated marginal means (SE) | T-tau subgroup pairwise comparisons p value | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tau PET SUVr | Subgroup | F | p value | Subgroup 1 | Subgroup 2 | Subgroup 3 | Subgroup 4 | 1 vs 2 | 1 vs 3 | 1 vs 4 | 2 vs 3 | 2 vs 4 | 3 vs 4 |
Braak I/II | T-tau | 28 | 3.69E−16 | 1.18 (0.016) | 1.22 (0.013) | 1.36 (0.018) | 1.51 (0.052) | 2.91E−02 | 1.91E−12 | 1.65E−09 | 8.36E−09 | 1.03E−07 | 4.78E−03 |
P-tau | 37.6 | 5.14E−21 | 1.18 (0.012) | 1.27 (0.014) | 1.43 (0.024) | 1.47 (0.049) | 1.02E−06 | 1.97E−18 | 1.95E−08 | 3.40E−08 | 1.22E−04 | 4.67E−01 | |
Braak III/IV | T-tau | 30 | 2.64E−17 | 1.13 (0.019) | 1.17 (0.016) | 1.34 (0.022) | 1.56 (0.061) | 5.19E−02 | 2.98E−12 | 6.58E−11 | 3.73E−09 | 3.08E−09 | 7.24E−04 |
P-tau | 31 | 1.04E−17 | 1.13 (0.014) | 1.23 (0.017) | 1.38 (0.029) | 1.51 (0.059) | 1.79E−05 | 1.50E−13 | 7.23E−10 | 7.87E−06 | 3.88E−06 | 4.08E−02 | |
Braak V/VI | T-tau | 16 | 7.49E−10 | 1.05 (0.018) | 1.09 (0.015) | 1.21 (0.021) | 1.32 (0.058) | 1.50E−01 | 3.80E−08 | 1.01E−05 | 2.69E−06 | 8.12E−05 | 5.80E−02 |
P-tau | 14.2 | 1.04E−08 | 1.06 (0.014) | 1.13 (0.016) | 1.22 (0.028) | 1.27 (0.056) | 4.88E−04 | 1.21E−07 | 1.97E−04 | 4.22E−03 | 1.49E−02 | 4.21E−01 | |