Table 8 T-tau and p-tau subgroup comparisons on annual change in CSF t-tau and p-tau values
From: Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts
Effect time | Interaction subgroup x time | Annual change (se) for each subgroup | p values pairwise comparisons in slope differences between subgroups | Baseline effect tau group | Baseline estimated marginal means (SE) for each subgroup | p values pairwise comparisons in baseline estimates between subgroups | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Biomarker: platform | F | p value | F | p value | Subgroup 1 | Subgroup 2 | Subgroup 3 | Subgroup 4 | 1 vs 2 | 1 vs 3 | 1 vs 4 | 2 vs 3 | 2 vs 4 | 3 vs 4 | F | p value | Subgroup 1 | Subgroup 2 | Subgroup 3 | Subgroup 4 | 1 vs 2 | 1 vs 3 | 1 vs 4 | 2 vs 3 | 2 vs 4 | 3 vs 4 | |
T-tau: Luminex | 14 | 1.74E−04 | 0.2 | 8.96E−01 | 1.72 (0.75) a | 2.03 (0.57) c | 2.2 (0.71) b | 1.08 (1.44) | 7.45E−01 | 6.43E−01 | 6.94E−01 | 8.50E−01 | 5.41E−01 | 4.86E−01 | 1318 | 7.48E−273 | 44.6 (1.89) | 76.4 (1.43) | 129.3 (1.73) | 221.9 (3.24) | 1.65E−36 | 1.83E−137 | 6.43E−206 | 1.68E−87 | 3.96E−177 | 3.88E−96 | |
T-tau: Elecsys | 37 | 2.55E−09 | 2.5 | 5.98E−02 | 3.34 (1.68) a | 4.8 (1.16) c | 8.71 (1.46) c | 8.36 (3.31) a | 4.74E−01 | 1.62E−02 | 1.77E−01 | 3.67E−02 | 3.11E−01 | 9.23E−01 | 1330 | 1.30E−261 | 162.4 (4.49) | 254.1 (3.05) | 392.8 (3.64) | 616.8 (7.86) | 7.82E−53 | 1.58E−168 | 1.28E−215 | 7.20E−117 | 1.89E−184 | 4.47E−99 | |
P-tau: Luminex | 2 | 1.63E−01 | 15 | 2.93E−09 | 3.17 (0.72) c | 4.67 (0.6) c | 2.89 (0.88) b | −15.23 (2.95) c | 1.11E−01 | 8.07E−01 | 2.58E−09 | 9.58E−02 | 8.98E−11 | 6.95E−09 | 808 | 6.11E−222 | 21.8 (1.06) | 39.1 (0.84) | 65.5 (1.22) | 109.5 (3.99) | 9.63E−33 | 2.98E−101 | 1.14E−73 | 5.97E−56 | 9.88E−54 | 7.98E−24 | |
P-tau: Elecsys | 0.005 | 2.85E−02 | 1.5 | 2.13E−01 | 0.26 (0.13)a | 0.48 (0.13) c | 0.49 (0.21) a | −0.22 (0.37) | 2.12E−01 | 3.28E−01 | 2.25E−01 | 9.68E−01 | 7.35E−02 | 9.28E−02 | 1456 | 3.10E−270 | 16.8 (0.36) | 28.4 (0.34) | 43.4 (0.52) | 66.0 (0.90) | 1.96E−181 | 7.62E−221 | 7.62E−221 | 1.64E−90 | 1.76E−167 | 6.98E−78 | |