Fig. 5
From: Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease
P for trend analysis of baseline 18F-florbetaben and 18F-flortaucipir SUVR and their longitudinal accumulation rates across the ApoE ε4-negative, heterozygous, and homozygous groups. Data are presented as means and standard deviations (error bars) of ε4-negative (blue), ε4-heterozygous (green), and ε4-homogygous (red) groups. Regions that showed significant differences in a dose-dependent manner after adjusting for sex, age, duration of education, and MMSE score (uncorrected P for trend < 0.05) and additionally survived correcting for region-wise multiple comparisons (false discovery rate-corrected P < 0.05) are presented as red bars. Blue dotted lines represent uncorrected P for trend = 0.05. Rightward direction of horizontal bars represents an SUVR value increased with higher numbers of ε4 alleles, while the leftward direction represents an SUVR value decreased with higher numbers of ε4 alleles. Aβ±, Aβ-positivity; ApoE, apolipoprotein E; SUVR, standardized uptake value ratio; A, 18F-florbetaben; T, 18F-flortaucipir