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Table 4 Correlations between baseline plasma biomarkers and other variables in the SMC population

From: Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study

 

Baseline plasma NFL (SMC = 316)

Baseline plasma t-Tau (SMC = 316)

ρs

P value

ρs

P value

Baseline

 Amyloid-PET

  SUVR

0.089

0.114

− 0.035

0.535

 Age

0.270

< 0.001

− 0.051

0.363

 FCSRT

− 0.031

0.585

− 0.031

0.584

 MMSE

− 0.059

0.295

0.019

0.742

 Plasma NFL

  

0.180

0.011

 Plasma T-Tau

0.180

0.011

  

 CSF NFLa

0.900

< 0.001

− 0.026

0.337

 CSF T-Taua

0.540

0.014

− 0.067

0.514

Follow-up

 Amyloid-PETb

  SUVR

0.074

0.229

0.016

0.797

  Δ SUVR

0.150

0.030

0.037

0.514

 FCSRTc

− 0.029

0.881

− 0.084

0.173

 MMSEc

− 0.130

0.029

0.044

0.477

 Δ FCSRTc

− 0.017

0.787

0.013

0.837

 Δ MMSEc

0.039

0.526

− 0.083

0.173

  1. AF atrial fibrillation, BMI body mass index, FCSRT free and cued selective reminding test, HTA arterial hypertension, IHD ischemic heart disease, MMSE Mini-Mental State Examination, NFL neurofilament light chain, OSAS obstructive sleep apnea syndrome, SD standard deviation, SMC subjective memory complaints, SUVR standardized uptake value ratio, t-Tau total Tau
  2. aReferred to a subsample of 40 SMC
  3. b2-year follow-up
  4. c3-year follow-up
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Alzheimer's Research & Therapy

ISSN: 1758-9193