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Table 1 Participant demographics and clinical characteristics at baseline

From: Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study

 

SMC tot. (n = 316)

SMC females (n = 200)

SMC males (n = 116)

p

Age, mean (SD)

76.1 (3.5)

76.1 (3.3)

76.1 (3.9)

NS

Plasma NFL, mean (SD), pg/mL

30.0 (13.0)

29.9 (11.8)

30.2 (14.8)

NS

Plasma t-Tau, mean (SD), pg/mL

4.5 (2.6)

4.7 (2.4)

4.3 (2.9)

NS

Amyloid PET SUVR, mean (SD)

0.7 (0.1)

0.7 (0.1)

0.7 (0.1)

NS

APOE ɛ4−, No. (%)

254 (80)

159 (79)

95 (82)

 

APOE ɛ4+, No. (%)

62 (20)

41 (21)

21 (18)

 

Cognitive score

 MMSE, mean (SD)

28.7 (1.0)

28.7 (1.0)

28.6 (1.0)

NS

 FCSRT, mean (SD)

46.1 (2.0)

46.1 (2.0)

45.4 (2.1)

NS

Clinical characteristics

 AF, No. (%)

28 (9)

16 (8)

12 (10)

NS

 BMI, mean (SD), Kg/m2

25.2 (3.5)

25.1 (3.8)

25.5 (2.9)

NS

 Diabetes, No. (%)

15 (5)

9 (4.5)

6 (5)

NS

 Dyslipidemia, No. (%)

133 (42)

80 (40)

53 (45)

NS

 Head trauma, No. (%)

26 (8)

20 (10)

6 (5)

NS

 HTA, No. (%)

129 (41)

71 (35)

58 (50)

0.013

 IHD, No. (%)

35 (11)

17 (8.5)

18 (15)

0.050

 Mood disorders, No. (%)

85 (27)

71 (35)

14 (12)

< 0.001

 OSAS, No. (%)

19 (6)

8 (4)

11 (9)

0.049

 Plasma Vit. B12 deficiency, No. (%)

6 (1.5)

4 (1.5)

2 (1)

NS

  1. AF atrial fibrillation, BMI body mass index, FCSRT free and cued selective reminding test, HTA arterial hypertension, IHD ischemic heart disease, MMSE Mini-Mental State Examination, NFL neurofilament light chain, OSAS obstructive sleep apnea syndrome, SD standard deviation, SMC subjective memory complaints, SUVR standardized uptake value ratio, t-Tau total Tau