Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia

Table 3 Results from the three sensitivity analyses to evaluate the robustness of the main findings

SCD trajectory	Additional adjustment for one-time assessment of SCD at year 4^a		Primary endpoint of dementia^a		Redefining the trajectories using simplified rules^{a, b}
SCD trajectory	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
No SCD	1.0 (Ref)	Ref	1.0 (Ref)	Ref	1.0 (Ref)	Ref
Intermittent SCD	1.4 (1.1–1.8)	0.011	1.5 (1.1–2.1)	0.010	1.5 (1.3–1.8)	< 0.001
Persistent SCD	2.1 (1.6–2.8)	< 0.001	2.2 (1.5–3.2)	< 0.001	2.6 (2.0–3.4)	< 0.001

SCD subjective cognitive decline, HR hazard ratio, CI confidence interval, Ref reference group
^aModel adjusted for baseline variables of age, sex, ethnicity, years of education, APOE e4 status, current smoking, diabetes mellitus, hypertension, hyperlipidemia, Mini-Mental State Examination score, total score on Geriatric Depression Scale, and presence of anxiety symptoms
^bThe following simplified rules were used to redefine the identified trajectories—No SCD was redefined as participants who reported SCD in none of the 4 annual visits, Intermittent SCD as those who reported SCD in 1 to 2 of the annual visits, and Persistent SCD as those who reported SCD in 3 to 4 of the annual visits

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