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Table 3 Results from the three sensitivity analyses to evaluate the robustness of the main findings

From: Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia

SCD trajectory Additional adjustment for one-time assessment of SCD at year 4a Primary endpoint of dementiaa Redefining the trajectories using simplified rulesa, b
HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value
No SCD 1.0 (Ref) Ref 1.0 (Ref) Ref 1.0 (Ref) Ref
Intermittent SCD 1.4 (1.11.8) 0.011 1.5 (1.12.1) 0.010 1.5 (1.31.8) < 0.001
Persistent SCD 2.1 (1.62.8) < 0.001 2.2 (1.53.2) < 0.001 2.6 (2.03.4) < 0.001
  1. SCD subjective cognitive decline, HR hazard ratio, CI confidence interval, Ref reference group
  2. aModel adjusted for baseline variables of age, sex, ethnicity, years of education, APOE e4 status, current smoking, diabetes mellitus, hypertension, hyperlipidemia, Mini-Mental State Examination score, total score on Geriatric Depression Scale, and presence of anxiety symptoms
  3. bThe following simplified rules were used to redefine the identified trajectories—No SCD was redefined as participants who reported SCD in none of the 4 annual visits, Intermittent SCD as those who reported SCD in 1 to 2 of the annual visits, and Persistent SCD as those who reported SCD in 3 to 4 of the annual visits