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Table 3 Results from the three sensitivity analyses to evaluate the robustness of the main findings

From: Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia

SCD trajectory

Additional adjustment for one-time assessment of SCD at year 4a

Primary endpoint of dementiaa

Redefining the trajectories using simplified rulesa, b

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

No SCD

1.0 (Ref)

Ref

1.0 (Ref)

Ref

1.0 (Ref)

Ref

Intermittent SCD

1.4 (1.1–1.8)

0.011

1.5 (1.1–2.1)

0.010

1.5 (1.3–1.8)

< 0.001

Persistent SCD

2.1 (1.6–2.8)

< 0.001

2.2 (1.5–3.2)

< 0.001

2.6 (2.0–3.4)

< 0.001

  1. SCD subjective cognitive decline, HR hazard ratio, CI confidence interval, Ref reference group
  2. aModel adjusted for baseline variables of age, sex, ethnicity, years of education, APOE e4 status, current smoking, diabetes mellitus, hypertension, hyperlipidemia, Mini-Mental State Examination score, total score on Geriatric Depression Scale, and presence of anxiety symptoms
  3. bThe following simplified rules were used to redefine the identified trajectories—No SCD was redefined as participants who reported SCD in none of the 4 annual visits, Intermittent SCD as those who reported SCD in 1 to 2 of the annual visits, and Persistent SCD as those who reported SCD in 3 to 4 of the annual visits
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Alzheimer's Research & Therapy

ISSN: 1758-9193