SCD trajectory
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Additional adjustment for one-time assessment of SCD at year 4a
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Primary endpoint of dementiaa
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Redefining the trajectories using simplified rulesa, b
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HR (95% CI)
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p value
|
HR (95% CI)
|
p value
|
HR (95% CI)
|
p value
|
---|
No SCD
|
1.0 (Ref)
|
Ref
|
1.0 (Ref)
|
Ref
|
1.0 (Ref)
|
Ref
|
Intermittent SCD
|
1.4 (1.1–1.8)
|
0.011
|
1.5 (1.1–2.1)
|
0.010
|
1.5 (1.3–1.8)
|
< 0.001
|
Persistent SCD
|
2.1 (1.6–2.8)
|
< 0.001
|
2.2 (1.5–3.2)
|
< 0.001
|
2.6 (2.0–3.4)
|
< 0.001
|
- SCD subjective cognitive decline, HR hazard ratio, CI confidence interval, Ref reference group
- aModel adjusted for baseline variables of age, sex, ethnicity, years of education, APOE e4 status, current smoking, diabetes mellitus, hypertension, hyperlipidemia, Mini-Mental State Examination score, total score on Geriatric Depression Scale, and presence of anxiety symptoms
- bThe following simplified rules were used to redefine the identified trajectories—No SCD was redefined as participants who reported SCD in none of the 4 annual visits, Intermittent SCD as those who reported SCD in 1 to 2 of the annual visits, and Persistent SCD as those who reported SCD in 3 to 4 of the annual visits