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Table 1 Comparison of participant characteristics (at year 4) across the three trajectories of subjective cognitive decline (n = 5661)

From: Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia

Variable No SCD (n = 3914) Intermittent SCD (n = 1022) Persistent SCD (n = 725) p valuea
Age, median (IQR) 74 (69–80) 75 (70–82) 75 (69–81) 0.002
Years of education, median (IQR) 16 (14–18) 16 (14–18) 16 (14–18) 0.719
Male sex, n (%) 1273 (32.5) 319 (31.2) 237 (32.7) 0.708
Ethnicity, n (%)     < 0.001
 White 3248 (83.0) 786 (76.9) 576 (79.5)  
 African American 479 (12.2) 180 (17.6) 100 (13.8)  
 Other/unknown 187 (4.8) 56 (5.5) 49 (6.8)  
APOE e4 genotype, n (%)     0.007
 Two copies of e4 allele 89 (2.3) 21 (2.1) 21 (2.9)  
 One copy of e4 allele 1012 (25.9) 249 (24.4) 198 (27.3)  
 No e4 allele 2615 (66.8) 678 (66.3) 449 (61.9)  
 Unknown 198 (5.1) 74 (7.2) 57 (7.9)  
Current smoker, n (%) 187 (4.8) 33 (3.2) 38 (5.2) 0.068
Diabetes mellitus, n (%) 480 (12.3) 145 (14.2) 105 (14.5) 0.103
Hypertension, n (%) 2154 (55.0) 584 (57.1) 391 (53.9) 0.356
Hyperlipidemia, n (%) 2211 (56.5) 609 (59.6) 425 (58.6) 0.153
MMSE score, median (IQR) 30 (29–30) 29 (28–30) 29 (28–30) < 0.001
GDS score, median (IQR) 0 (0–1) 1 (0–2) 1 (0–3) < 0.001
Presence of anxiety symptoms, n (%) 209 (5.3) 100 (9.8) 79 (10.9) < 0.001
  1. IQR interquartile range, MMSE Mini-Mental State Examination, GDS Geriatric Depression Scale, SCD subjective cognitive decline
  2. aTest of difference across the three trajectories of SCD: chi-square test for categorical variables, and Kruskal-Wallis test for continuous variables. Bold-faced p values are ≤ 0.05