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Table 3 Mixed-effects linear models of cognitive and physical functions by Aβ+NfL+ conditions

From: Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults

Parameters Aβ+NfL+ group × time (all participants)# Aβ+NfL+ group × time (with APOE)#
Coefficient p Adjusted p 95%CI Coefficient p Adjusted p 95%CI
CCS − 0.11 0.0004 0.002 (− 0.17, − 0.05) − 0.09 0.007 0.03 (− 0.15, − 0.02)
MMSE − 0.14 0.18 0.24 (− 0.34, 0.06) − 0.06 0.55 0.74 (− 0.27, 0.14)
Gait speed (m/s) − 0.03 0.02 0.04 (− 0.05, − 0.005) − 0.02 0.08 0.17 (− 0.05, 0.003)
Chair-stand time (s) 0.08 0.66 0.66 (− 0.28, 0.44) − 0.001 0.99 0.99 (− 0.38, 0.38)
  1. Covariates: age, sex, body mass index, education level and MAPT group
  2. #Participants without Aβ+NfL+ condition as the reference
  3. p value adjusted by Benjamini–Hochberg procedure