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Table 2 Multivariable linear regression of cognitive and physical functions by Aβ+NfL+ conditions

From: Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults

Parameters Aβ+NfL+ group (all participants) # Aβ+NfL+ group (with APOE)#
Coefficient p Adjusted p 95%CI Coefficient p Adjusted p 95%CI
Initial CCS − 0.19 0.11 0.45 (− 0.42, 0.04) − 0.15 0.24 0.85 (− 0.39, 0.10)
Initial MMSE − 0.02 0.93 0.93 (− 0.60, 0.55) − 0.03 0.92 0.92 (− 0.57,0.64)
Initial gait speed (m/s) − 0.01 0.87 0.93 (− 0.08, 0.07) − 0.02 0.63 0.85 (− 0.10, 0.06)
Initial chair-stand time (s) 0.34 0.61 0.93 (− 1.00, 1.69) 0.50 0.50 0.85 (− 0.95, 1.94)
  1. Covariates: age, sex, body mass index, education level and MAPT group
  2. #Participants without Aβ+NfL+ condition as the reference
  3. p value adjusted by Benjamini–Hochberg procedure