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Table 1 Characteristics of participants in this study

From: Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults

Parameters All participants Participants with APOE genotype data
Total (n = 452) Aβ+NfL+ group (n = 46) Other participants (n = 406) Total (n = 410) Aβ+NfL+ group (n = 39) Other participants (n = 371)
Age (year), mean (SD) 76 (5) 78 (5)** 76 (5) 76 (5) 78 (5)** 76 (5)
Female, n (%) 268 (59%) 23 (50%) 245 (60%) 224 (55%) 19 (49%) 224 (60%)
Participants with plasma biomarkers measured in the first year, n (%) 420 (93%) 44 (96%) 376 (93%) 382 (93%) 37 (95%) 345 (93%)
Initial body mass index, mean (SD) 26.4 (4.0) 25.9 (3.8) 26.5 (3.9) 26.4 (3.8) 25.6 (3.1) 26.5 (3.9)
Initial CCS, mean (SD) 0.07 (0.79) − 0.25 (0.70)** 0.10 (0.79) 0.10 (0.77) − 0.20 (0.71)* 0.14 (0.78)
Initial MMSE, mean (SD) 27.8 (1.9) 27.5 (1.7) 27.9 (1.9) 27.9 (1.8) 27.7 (1.6) 27.9 (1.8)
Initial gait speed (m/s), mean (SD) 1.0 (0.2) 1.0 (0.3) 1.0 (0.2) 1.0 (0.2) 1.0 (0.3) 1.0 (0.2)
Initial chair-stand time (s), mean (SD) 12.1 (4.3) 12.9 (4.0) 12.0 (4.4) 12.0 (4.3) 12.9 (4.2) 11.9 (4.3)
42/Aβ40 ratio, mean (SD) 0.114 (0.018) 0.097 (0.010)** 0.116 (0.018) 0.113 (0.018) 0.096 (0.010)** 0.115 (0.018)
NfL (pg/ml), mean (SD) 86.65 (74.09) 160.35 (137.01)** 78.30 (57.79) 85.70 (75.50) 162.55 (143.15)** 77.62 (59.23)
  1. *p < 0.05, **p < 0.01 when compared Aβ+NfL+ group with other participants
  2. Other participants without Aβ+NfL+ condition