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Table 2 Age-adjusted Pearson’s correlation between Aβ40 and Aβ42, tau, or p-tau (181) values in the six cohorts (Montpellier 1 (Mtp-1), Montpellier 2 (Mtp-2), Paris, SPIN-Barcelona, ADNI-MS, ADNI-Elecsys), in the overall population using mean-centered values to account for level differences between analytical methods

From: Cerebrospinal fluid A beta 1–40 peptides increase in Alzheimer’s disease and are highly correlated with phospho-tau in control individuals

Aß40 correlation

All

NAD or ADNI(−)

AD or ADNI(+)

p-Tau

Tau

Aß42

p-Tau

Tau

Aß42

p-Tau

Tau

Aß42

Mtp-1

0.501

0.377

0.520

0.557

0.235*

0.764

0.504

0.443

0.613

Mtp-2

0.514

0.443

0.407

0.430

0.244

0.533

0.304

0.213*

0.469

Paris

0.419

0.36

0.188

0.421

0.145*

0.571

0.288

0.245

0.247

SPIN-Barcelona

0.468

0.396

0.161

0.483

0.348

0.419

0.355

0.256*

0.308*

ADNI-MS

0.254

0.413

0.505

0.257

0.496

0.705

0.223*

0.470

0.574

ADNI-Elecsys

0.536

0.567

0.449

0.487

0.624

0.782

0.502

0.496

0.580

Overall

0.445

0.418

0.368

0.455

0.318

0.615

0.339

0.318

0.426

  1. Computation has been done in the All population and in the NAD, AD, ADNI(−), and ADNI(+) groups. Correlation coefficient statistical value P < 0.001 for all but *P < 0.01