Fig. 3

Aβ40 in different diagnoses; representation in percentile; AD odds ratio, age, and p-tau (181) distribution. The Montpellier, Paris, and SPIN-Barcelona cohorts displayed a large range of pathological samples from patients with Alzheimer’s disease (AD), mild cognitive impairment (MCI), frontotemporal dementia (FTD), Control (subjective cognitive impairment), and the other neurological diseases (Other) (see also Sup-Figure 3). Mean-centered Aβ40 values in these cohorts were combined and compared in the different clinical groups confirming the significant increase of the peptides in AD (a). The four cohorts (Montpellier 1 (Mtp-1), Montpellier 2 (Mtp-2), Paris, SPIN-Barcelona) have been sorted in four classes based on their Aβ40 percentile values as follows: p25, < 25th percentile; p25–50, 25th–50th percentile; p50–75, 50th–75th percentile; and p75, > 75th. The odds ratio for AD (b), the age of the patients (c), and the concentration of CSF p-tau (181) (d) were then plotted in each percentile class. Significant differences between classes are indicated