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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Cerebrospinal fluid A beta 1–40 peptides increase in Alzheimer’s disease and are highly correlated with phospho-tau in control individuals

Fig. 2

Meta-analysis including the four independent cohorts. We used with to compare the Aβ40 means between AD and NAD populations the Hedges g statistic as a formulation for the standardized mean difference (SMD) under the fixed effects model. The SMD Hedges g is the difference between the two means divided by the pooled standard deviation. The plot has marker sizes relative to study weight. The results of the different studies, with 95% CI, and the overall standardized mean difference with 95% CI are shown. Cohen’s rule of thumb for interpretation of the SMD statistic is that a value of 0.2 indicates a small effect, a value of 0.5 indicates a medium effect, and a value of 0.8 or larger indicates a large effect

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Alzheimer's Research & Therapy

ISSN: 1758-9193