Table 1 Descriptive statistics and demographics of the FAD cohort in this study
Mutation carriers | Non-carriers | U (*χ2) | p | |
|---|---|---|---|---|
N | 21 | 14 | – | – |
Age | 38.9 (33.6, 42.0) | 39.5 (33.9, 43.5) | 131 | 0.30 |
Sex, M/F | 11/10 | 6/8 | *0.0429 | 0.84 |
EYO | − 6.5 (− 9.2, − 5.0) | − 7.7 (− 12.6, − 0.6) | 134 | 0.34 |
Years of education | 14 (12, 16) | 14 (13, 17) | 125 | 0.23 |
ALF– Story | 66.8 (59.8, 81.9) | 93.1 (85.1, 95.2) | 47 | 0.0004 |
– Figure | 70.2 (60.2, 79.4) | 88.2 (77.7, 91.2) | 45 | 0.0027 |
– List | 43.7 (27.3, 59.7) | 71.4 (58.8, 76.4) | 54 | 0.0009 |
EMQ | 18.3 (11.9, 27.6) | 11.2 (8.7, 13.3) | 62 | 0.0022 |
DSST | 57.1 (47.1, 62.4) | 69.1 (58.6, 74.5) | 62 | 0.032 |
Digit Span – fwd | 10.1 (7.4, 10.7) | 10.0 (9.4, 11.6) | 84 | 0.085 |
– back | 8.9 (6.6, 9.6) | 9.0 (6.9, 9.9) | 110 | 0.31 |
PIQ | 108.4 (98.0, 113.6) | 116.9 (109.0, 126.4) | 60 | 0.01 |
VIQ | 101.8 (98.0, 107.4) | 104.1 (97.3, 114.1) | 100 | 0.26 |
Stroop | 50.0 (45.0, 57.6) | 47.8 (38.5, 48.7) | 77 | 0.076 |
RMT– words | 49.3 (48.6, 49.7) | 49.0 (48.1, 49.3) | 78 | 0.054 |
– faces | 43.2 (40.7, 47.9) | 43.5 (42.0, 45.6) | 100 | 0.26 |
MMSE | 29.7 (29.1, 29.9) | 29.4 (29.3, 29.7) | 84 | 0.14 |
Dementia Index | − 4.6 (− 7.9, 2.6) | − 3.7 (− 11.1, 2.6) | 100 | 0.27 |
GDA | 14.1 (8.8, 16.6) | 16.7 (13.0, 19.5) | 82 | 0.074 |
PAL | 18.4 (14.2, 22.9) | 18.4 (16.7, 19.9) | 110 | 0.43 |