Cognitive training and brain stimulation in prodromal Alzheimer’s disease (AD-Stim)—study protocol for a double-blind randomized controlled phase IIb (monocenter) trial

Table 2 Neuroimaging data acquisition parameters

Sequence	Main parameters
Resting-state fMRI	TR = 2000 ms, TE = 30 ms, FOV 192 × 192 mm², 34 slices, 176 volumes, descending acquisition, 3.0 × 3.0 × 3.0 mm³, flip angle 90°
T1 MPRAGE	TR = 2300 ms, TE =2.96 ms, TI = 900 ms, 192 slices, 1.0 × 1.0 × 1.0 mm³, flip angle 9°
DTI	TR = 11,100 ms, TE = 107 ms, 70 slices, 1.8 × 1.8 × 2.0mm³, 64 directions (b = 1000 s/mm²)
FLAIR	TR = 5000 ms, TE = 388 ms, 160 slices, 1.0 × 1.0 × 1.0 mm³
T1w	TR = 1690 ms, TE = 2.52 ms, TI = 900 ms, 176 slices, 1.0 × 1.0 × 1.0 mm³, flip angle 9°, using selective water excitation for fat suppression
T2w	TR = 12,770 ms, TE = 86.0 ms, 96 slices, 1.0 × 1.0 × 1.0 mm³, flip angle 111°

Abbreviations: TR repetition time, TE echo time, TI inversion time, FOV field of view, fMRI functional magnetic resonance imaging, DTI diffusion tensor imaging, FLAIR fluid-attenuated inversion recovery, MPRAGE magnetization prepared rapid acquisition gradient echo

ISSN: 1758-9193