Table 3 Recalculated cutoffs for freshly measured CSF core AD biomarkers with their 95% CI. Cutoff fresh R: cutoff transferred by applying Passing Bablok regression. Cutoff fresh Y: cutoff calculated maximizing the Youden’s index for fresh samples, by taking as reference the classification performed on frozen ones
Biomarker | Cutoff frozen | Cutoff fresh R (95%CI) | Cutoff fresh Y (95%CI) |
|---|---|---|---|
Aβ42/Aβ40 | 0.069 | 0.067 (0.060, 0.075) | 0.062 (0.061, 0.075) |
p-tau | 56.5 | 57.2 (55.7, 59.7) | 55.1 (52.3, 60.9) |
t-tau | 404 | 419 (379, 473) | 419 (406, 581) |