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Table 2 Classification of core AD biomarkers and in fresh and frozen samples by using the A/T/(N) criteria. Number of changes in classification between biomarkers measured in fresh and stored at − 80 °C CSF samples are also reported. Samples with both pathologic Aβ42/Aβ40 ratio and pathologic p-tau (A+/T+) have been classified positive for AD. For “robust” AD diagnosis and AD exclusion (non-AD) a ± 10% tolerance was applied on the cutoffs of Aβ42/Aβ40 ratio and p-tau

From: Measurement of CSF core Alzheimer disease biomarkers for routine clinical diagnosis: do fresh vs frozen samples differ?

 

+ (%)

− (%)

No. of changes (%)

Aβ42/Aβ40 frozen

39 (67%)

19 (33%)

1 (2%)

Aβ42/Aβ40 fresh

40 (69%)

18 (31%)

p-tau frozen

34 (59%)

24 (41%)

0 (0%)

p-tau fresh

34 (59%)

24 (41%)

t-tau frozen

34 (59%)

24 (41%)

2 (3%)

t-tau fresh

36 (62%)

22 (38%)

AD frozen

34 (59%)

24 (41%)

0 (0%)

AD fresh

34 (59%)

24 (41%)

Robust AD frozen

32 (55%)

26 (45%)

1 (2%)

Robust AD fresh

33 (57%)

25 (43%)

Robust non-AD frozen

24 (41%)

34 (59%)

1 (2%)

Robust non-AD fresh

23 (40%)

35 (60%)