Fig. 5

Prediction of annual changes in global cortical SUVR values by baseline PC scores in 78 Aβ-positive individuals who completed follow-up tau PET. The X-axes represent measured annual changes based on baseline and follow-up tau PET scans. Y-axes represent changes predicted by PC1 scores (a–c) and both PC1 and PC2 scores (d–f) after adjustment for age, years of education, sex, and presence of ApoE ε4 allele. Plots for all 78 Aβ-positive individuals (a, d), 39 individuals in the training set (b, e), and 39 individuals in the test set (c, f). Linear regression lines (solid), 95% confidence interval lines (dotted), intraclass correlation coefficient (ICC), R², and P values are presented within each plot. PC, principal component