Fig. 2

Expression of Aβ-positive AD dementia-specific PCs and global cortical tau burden. a The percentages of variance explained by the first 10 PCs (red bars) and their cumulative percentages (light blue bars). The first two PCs (PC1 and PC2) contributed to 44% and 11% of total variance, respectively. b Scatter plot of individual scores for PC1 and PC2 expression exhibited divergence of PC2 scores with increased PC1 scores. c PC1 scores clearly reflect the cortical tau burden measured by global cortical SUVR. d PC2 scores were likely to increase with the global cortical SUVR; however, there was a divergence of PC2 scores among individuals with a higher tau burden. The colors of the circles represent individual clinical status (blue = CU, green = MCI, and red = dementia), and the closed and open circles represent Aβ-positive and Aβ-negative individuals, respectively. Pearson’s correlation lines (solid), 95% confidence interval lines (dotted), correlation coefficients (R), and P values are presented in green color (all 272 individuals) or red color (114 Aβ-positive individuals). PC, principal component; AD, Alzheimer’s disease; MCI, mild cognitive impairment; CU, cognitively unimpaired