Fig. 1

Voxel-wise maps for Aβ-positive AD dementia-specific PCs of tau PET and group-wise averaged tau PET images for each quartile of PC scores in 114 Aβ-positive individuals. Individual PC1 scores correlated with the tau uptake in the entire cortex and there was an increasing trend of cortical tau burden with the advancement of the PC1 quartile groups. Individual PC2 scores correlated with the tau uptake in the prefrontal, parietal, occipital, and posterior cingulate cortices. The lowest PC2 quartile group (Q1) showed a temporal predominance pattern while the highest PC2 quartile group (Q4) showed a parietal predominance pattern. Significance maps for the voxel-wise correlation analysis between the individual scores for the PCs and tau uptake are overlaid on the template. Only the voxels that survived after correcting for multiple comparisons with family-wise error (P < 0.05) are displayed. Color bars represent PCs (bidirectional cold and hot colors), −Log₁₀P (rainbow color) and SUVR (rainbow color). PC, principal component; AD, Alzheimer’s disease; SUVR, standardized uptake value ratio; Qn, quartiles