Table 4 Association of cerebrospinal fluid (CSF) level of metabolites with t-tau levels in CSF
ACE cohort | Heidelberg/Mannheim cohort | Meta-analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
β | SE | P value | β | SE | P value | β | SE | Direction | P value | FDR | |
LPA C20:1 | 0.318 | 0.085 | 2.89 × 10−4 | 0.391 | 0.181 | 3.76 × 10−2 | 0.331 | 0.077 | ++ | 1.79 × 10−5 | 3.40 × 10−4 |
Isomer-LPA C22:5 | 0.271 | 0.081 | 1.05 × 10−3 | 0.390 | 0.184 | 4.14 × 10−2 | 0.290 | 0.074 | ++ | 8.88 × 10−5 | 8.07 × 10−4 |
LPA C22:6 | 0.268 | 0.081 | 1.22 × 10−3 | 0.409 | 0.200 | 4.84 × 10−2 | 0.288 | 0.075 | ++ | 1.27 × 10−4 | 8.07 × 10−4 |
LPA C16:0 | 0.227 | 0.079 | 4.42 × 10−3 | 0.461 | 0.218 | 4.18 × 10−2 | 0.254 | 0.074 | ++ | 5.80 × 10−4 | 2.75 × 10−3 |
LPA C16:1 | 0.236 | 0.084 | 5.67 × 10−3 | 0.280 | 0.187 | 1.44 × 10−1 | 0.244 | 0.077 | ++ | 1.48 × 10−3 | 5.63 × 10−3 |
LPA C22:4 | 0.185 | 0.080 | 2.21 × 10−2 | 0.361 | 0.203 | 8.51 × 10−2 | 0.209 | 0.074 | ++ | 5.05 × 10−3 | 1.60 × 10−2 |
LPA C18:1 | 0.230 | 0.097 | 1.93 × 10−2 | 0.190 | 0.223 | 3.99 × 10−1 | 0.224 | 0.089 | ++ | 1.20 × 10−2 | 3.26 × 10−2 |
aLPA C18:1 | 0.125 | 0.125 | 3.18 × 10−1 | 0.488 | 0.175 | 8.52 × 10−3 | 0.248 | 0.102 | ++ | 1.46 × 10−2 | 3.48 × 10−2 |
LPA C20:3 | 0.070 | 0.099 | 4.83 × 10−1 | 0.504 | 0.163 | 4.06 × 10−3 | 0.187 | 0.085 | ++ | 2.78 × 10−2 | 5.86 × 10−2 |
LPA C14:0 | 0.156 | 0.089 | 8.13 × 10−2 | 0.196 | 0.194 | 3.19 × 10−1 | 0.163 | 0.081 | ++ | 4.36 × 10−2 | 7.58 × 10−2 |
cLPA C18:0 | 0.166 | 0.087 | 5.88 × 10−2 | 0.140 | 0.210 | 5.11 × 10−1 | 0.162 | 0.080 | ++ | 4.39 × 10−2 | 7.58 × 10−2 |
aLPA C16:1 | 0.093 | 0.128 | 4.70 × 10−1 | 0.377 | 0.172 | 3.54 × 10−2 | 0.194 | 0.103 | ++ | 5.89 × 10−2 | 9.32 × 10−2 |
cLPA C18:1 | 0.110 | 0.090 | 2.26 × 10−1 | 0.202 | 0.201 | 3.21 × 10−1 | 0.126 | 0.082 | ++ | 1.28 × 10−1 | 1.87 × 10−1 |
LPA C20:4 | 0.084 | 0.094 | 3.68 × 10−1 | 0.245 | 0.180 | 1.83 × 10−1 | 0.119 | 0.083 | ++ | 1.54 × 10−1 | 2.08 × 10−1 |
LPA C18:0 | 0.112 | 0.087 | 2.01 × 10−1 | 0.050 | 0.198 | 8.03 × 10−1 | 0.102 | 0.080 | ++ | 2.01 × 10−1 | 2.55 × 10−1 |
LPA C22:5 | 0.026 | 0.085 | 7.59 × 10−1 | 0.407 | 0.189 | 3.88 × 10−2 | 0.090 | 0.078 | ++ | 2.46 × 10−1 | 2.92 × 10−1 |
cLPA C16:0 | 0.110 | 0.102 | 2.83 × 10−1 | 0.021 | 0.207 | 9.18 × 10−1 | 0.092 | 0.091 | ++ | 3.11 × 10−1 | 3.48 × 10−1 |
LPA C18:2 | − 0.041 | 0.082 | 6.19 × 10−1 | 0.106 | 0.183 | 5.66 × 10−1 | − 0.016 | 0.075 | −+ | 8.27 × 10−1 | 8.60 × 10−1 |
LPA C20:5 | − 0.007 | 0.087 | 9.39 × 10−1 | 0.128 | 0.203 | 5.34 × 10−1 | 0.014 | 0.080 | −+ | 8.60 × 10−1 | 8.60 × 10−1 |