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Table 4 Association of cerebrospinal fluid (CSF) level of metabolites with t-tau levels in CSF

From: Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease

  ACE cohort Heidelberg/Mannheim cohort Meta-analysis
β SE P value β SE P value β SE Direction P value FDR
LPA C20:1 0.318 0.085 2.89 × 10−4 0.391 0.181 3.76 × 10−2 0.331 0.077 ++ 1.79 × 10−5 3.40 × 10−4
Isomer-LPA C22:5 0.271 0.081 1.05 × 10−3 0.390 0.184 4.14 × 10−2 0.290 0.074 ++ 8.88 × 10−5 8.07 × 10−4
LPA C22:6 0.268 0.081 1.22 × 10−3 0.409 0.200 4.84 × 10−2 0.288 0.075 ++ 1.27 × 10−4 8.07 × 10−4
LPA C16:0 0.227 0.079 4.42 × 10−3 0.461 0.218 4.18 × 10−2 0.254 0.074 ++ 5.80 × 10−4 2.75 × 10−3
LPA C16:1 0.236 0.084 5.67 × 10−3 0.280 0.187 1.44 × 10−1 0.244 0.077 ++ 1.48 × 10−3 5.63 × 10−3
LPA C22:4 0.185 0.080 2.21 × 10−2 0.361 0.203 8.51 × 10−2 0.209 0.074 ++ 5.05 × 10−3 1.60 × 10−2
LPA C18:1 0.230 0.097 1.93 × 10−2 0.190 0.223 3.99 × 10−1 0.224 0.089 ++ 1.20 × 10−2 3.26 × 10−2
aLPA C18:1 0.125 0.125 3.18 × 10−1 0.488 0.175 8.52 × 10−3 0.248 0.102 ++ 1.46 × 10−2 3.48 × 10−2
LPA C20:3 0.070 0.099 4.83 × 10−1 0.504 0.163 4.06 × 10−3 0.187 0.085 ++ 2.78 × 10−2 5.86 × 10−2
LPA C14:0 0.156 0.089 8.13 × 10−2 0.196 0.194 3.19 × 10−1 0.163 0.081 ++ 4.36 × 10−2 7.58 × 10−2
cLPA C18:0 0.166 0.087 5.88 × 10−2 0.140 0.210 5.11 × 10−1 0.162 0.080 ++ 4.39 × 10−2 7.58 × 10−2
aLPA C16:1 0.093 0.128 4.70 × 10−1 0.377 0.172 3.54 × 10−2 0.194 0.103 ++ 5.89 × 10−2 9.32 × 10−2
cLPA C18:1 0.110 0.090 2.26 × 10−1 0.202 0.201 3.21 × 10−1 0.126 0.082 ++ 1.28 × 10−1 1.87 × 10−1
LPA C20:4 0.084 0.094 3.68 × 10−1 0.245 0.180 1.83 × 10−1 0.119 0.083 ++ 1.54 × 10−1 2.08 × 10−1
LPA C18:0 0.112 0.087 2.01 × 10−1 0.050 0.198 8.03 × 10−1 0.102 0.080 ++ 2.01 × 10−1 2.55 × 10−1
LPA C22:5 0.026 0.085 7.59 × 10−1 0.407 0.189 3.88 × 10−2 0.090 0.078 ++ 2.46 × 10−1 2.92 × 10−1
cLPA C16:0 0.110 0.102 2.83 × 10−1 0.021 0.207 9.18 × 10−1 0.092 0.091 ++ 3.11 × 10−1 3.48 × 10−1
LPA C18:2 − 0.041 0.082 6.19 × 10−1 0.106 0.183 5.66 × 10−1 − 0.016 0.075 −+ 8.27 × 10−1 8.60 × 10−1
LPA C20:5 − 0.007 0.087 9.39 × 10−1 0.128 0.203 5.34 × 10−1 0.014 0.080 −+ 8.60 × 10−1 8.60 × 10−1
  1. Direction column indicates the direction of regression coefficient of association in the ACE and Heidelberg/Mannheim cohort respectively
  2. Abbreviations: LPA lysophosphatidic acid, cLPA cyclic lysophosphatidic acid, aLPA alkyl-Lysophosphatidic acid, SE standard error, FDR false discovery rate