| |
ACE cohort
|
Heidelberg/Mannheim cohort
|
Meta-analysis
|
|---|
|
β
|
SE
|
P value
|
β
|
SE
|
P value
|
β
|
SE
|
Direction
|
P value
|
FDR
|
|---|
|
LPA C20:1
|
0.318
|
0.085
|
2.89 × 10−4
|
0.391
|
0.181
|
3.76 × 10−2
|
0.331
|
0.077
|
++
|
1.79 × 10−5
|
3.40 × 10−4
|
|
Isomer-LPA C22:5
|
0.271
|
0.081
|
1.05 × 10−3
|
0.390
|
0.184
|
4.14 × 10−2
|
0.290
|
0.074
|
++
|
8.88 × 10−5
|
8.07 × 10−4
|
|
LPA C22:6
|
0.268
|
0.081
|
1.22 × 10−3
|
0.409
|
0.200
|
4.84 × 10−2
|
0.288
|
0.075
|
++
|
1.27 × 10−4
|
8.07 × 10−4
|
|
LPA C16:0
|
0.227
|
0.079
|
4.42 × 10−3
|
0.461
|
0.218
|
4.18 × 10−2
|
0.254
|
0.074
|
++
|
5.80 × 10−4
|
2.75 × 10−3
|
|
LPA C16:1
|
0.236
|
0.084
|
5.67 × 10−3
|
0.280
|
0.187
|
1.44 × 10−1
|
0.244
|
0.077
|
++
|
1.48 × 10−3
|
5.63 × 10−3
|
|
LPA C22:4
|
0.185
|
0.080
|
2.21 × 10−2
|
0.361
|
0.203
|
8.51 × 10−2
|
0.209
|
0.074
|
++
|
5.05 × 10−3
|
1.60 × 10−2
|
|
LPA C18:1
|
0.230
|
0.097
|
1.93 × 10−2
|
0.190
|
0.223
|
3.99 × 10−1
|
0.224
|
0.089
|
++
|
1.20 × 10−2
|
3.26 × 10−2
|
|
aLPA C18:1
|
0.125
|
0.125
|
3.18 × 10−1
|
0.488
|
0.175
|
8.52 × 10−3
|
0.248
|
0.102
|
++
|
1.46 × 10−2
|
3.48 × 10−2
|
|
LPA C20:3
|
0.070
|
0.099
|
4.83 × 10−1
|
0.504
|
0.163
|
4.06 × 10−3
|
0.187
|
0.085
|
++
|
2.78 × 10−2
|
5.86 × 10−2
|
|
LPA C14:0
|
0.156
|
0.089
|
8.13 × 10−2
|
0.196
|
0.194
|
3.19 × 10−1
|
0.163
|
0.081
|
++
|
4.36 × 10−2
|
7.58 × 10−2
|
|
cLPA C18:0
|
0.166
|
0.087
|
5.88 × 10−2
|
0.140
|
0.210
|
5.11 × 10−1
|
0.162
|
0.080
|
++
|
4.39 × 10−2
|
7.58 × 10−2
|
|
aLPA C16:1
|
0.093
|
0.128
|
4.70 × 10−1
|
0.377
|
0.172
|
3.54 × 10−2
|
0.194
|
0.103
|
++
|
5.89 × 10−2
|
9.32 × 10−2
|
|
cLPA C18:1
|
0.110
|
0.090
|
2.26 × 10−1
|
0.202
|
0.201
|
3.21 × 10−1
|
0.126
|
0.082
|
++
|
1.28 × 10−1
|
1.87 × 10−1
|
|
LPA C20:4
|
0.084
|
0.094
|
3.68 × 10−1
|
0.245
|
0.180
|
1.83 × 10−1
|
0.119
|
0.083
|
++
|
1.54 × 10−1
|
2.08 × 10−1
|
|
LPA C18:0
|
0.112
|
0.087
|
2.01 × 10−1
|
0.050
|
0.198
|
8.03 × 10−1
|
0.102
|
0.080
|
++
|
2.01 × 10−1
|
2.55 × 10−1
|
|
LPA C22:5
|
0.026
|
0.085
|
7.59 × 10−1
|
0.407
|
0.189
|
3.88 × 10−2
|
0.090
|
0.078
|
++
|
2.46 × 10−1
|
2.92 × 10−1
|
|
cLPA C16:0
|
0.110
|
0.102
|
2.83 × 10−1
|
0.021
|
0.207
|
9.18 × 10−1
|
0.092
|
0.091
|
++
|
3.11 × 10−1
|
3.48 × 10−1
|
|
LPA C18:2
|
− 0.041
|
0.082
|
6.19 × 10−1
|
0.106
|
0.183
|
5.66 × 10−1
|
− 0.016
|
0.075
|
−+
|
8.27 × 10−1
|
8.60 × 10−1
|
|
LPA C20:5
|
− 0.007
|
0.087
|
9.39 × 10−1
|
0.128
|
0.203
|
5.34 × 10−1
|
0.014
|
0.080
|
−+
|
8.60 × 10−1
|
8.60 × 10−1
|
- Direction column indicates the direction of regression coefficient of association in the ACE and Heidelberg/Mannheim cohort respectively
- Abbreviations: LPA lysophosphatidic acid, cLPA cyclic lysophosphatidic acid, aLPA alkyl-Lysophosphatidic acid, SE standard error, FDR false discovery rate
