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Table 2 Association of cerebrospinal fluid (CSF) level of metabolites with Aβ-42 levels in CSF

From: Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease

  ACE cohort Heidelberg/Mannheim cohort Meta-analysis
β SE P value β SE P value β SE Direction P value FDR
LPA C18:1 0.286 0.100 4.85 × 10−3 0.260 0.199 2.00 × 10−1 0.281 0.089 ++ 1.65 × 10−3 1.26 × 10−2
LPA C16:1 0.264 0.087 2.81 × 10−3 0.150 0.175 3.97 × 10−1 0.242 0.078 ++ 1.88 × 10−3 1.26 × 10−2
LPA C16:0 0.249 0.081 2.61 × 10−3 0.134 0.209 5.27 × 10−1 0.234 0.076 ++ 2.00 × 10−3 1.26 × 10−2
LPA C22:6 0.199 0.086 2.19 × 10−2 0.372 0.181 4.76 × 10−2 0.231 0.078 ++ 2.91 × 10−3 1.38 × 10−2
LPA C14:0 0.220 0.092 1.76 × 10−2 0.232 0.175 1.92 × 10−1 0.223 0.081 ++ 6.04 × 10−3 2.29 × 10−2
LPA C22:4 0.150 0.084 7.59 × 10−2 0.393 0.184 4.02 × 10−2 0.191 0.076 ++ 1.20 × 10−2 3.79 × 10−2
LPA C20:4 0.211 0.096 2.91 × 10−2 0.178 0.165 2.89 × 10−1 0.203 0.083 ++ 1.44 × 10−2 3.90 × 10−2
Isomer-LPA C22:5 0.208 0.086 1.61 × 10−2 0.071 0.177 6.90 × 10−1 0.183 0.077 ++ 1.78 × 10−2 4.23 × 10−2
LPA C18:0 0.172 0.090 5.65 × 10−2 0.211 0.176 2.39 × 10−1 0.180 0.080 ++ 2.39 × 10−2 5.05 × 10−2
LPA C18:2 0.189 0.083 2.51 × 10−2 0.028 0.170 8.69 × 10−1 0.158 0.075 ++ 3.50 × 10−2 6.65 × 10−2
cLPA C18:1 0.170 0.093 7.03 × 10−2 0.055 0.186 7.68 × 10−1 0.147 0.083 ++ 7.77 × 10−2 1.34 × 10−1
LPA C22:5 0.112 0.088 2.04 × 10−1 0.230 0.179 2.09 × 10−1 0.135 0.079 ++ 8.70 × 10−2 1.35 × 10−1
LPA C20:1 0.164 0.092 7.59 × 10−2 0.038 0.175 8.29 × 10−1 0.137 0.081 ++ 9.21 × 10−2 1.35 × 10−1
cLPA C16:0 0.199 0.105 5.91 × 10−2 − 0.046 0.187 8.06 × 10−1 0.141 0.091 +− 1.23 × 10−1 1.67 × 10−1
aLPA C18:1 0.335 0.127 9.31 × 10−3 − 0.225 0.174 2.04 × 10−1 0.140 0.103 +− 1.72 × 10−1 2.17 × 10−1
cLPA C18:0 0.085 0.091 3.54 × 10−1 0.036 0.193 8.55 × 10−1 0.076 0.082 ++ 3.58 × 10−1 4.25 × 10−1
aLPA C16:1 0.199 0.132 1.35 × 10−1 − 0.106 0.166 5.30 × 10−1 0.081 0.103 +− 4.33 × 10−1 4.84 × 10−1
LPA C20:3 0.124 0.103 2.29 × 10−1 − 0.104 0.169 5.41 × 10−1 0.062 0.088 +− 4.77 × 10−1 5.04 × 10−1
LPA C20:5 − 0.114 0.090 2.08 × 10−1 0.253 0.185 1.80 × 10−1 − 0.044 0.081 −+ 5.88 × 10−1 5.88 × 10−1
  1. Direction column indicates the direction of regression coefficient of association in the ACE and Heidelberg/Mannheim cohort respectively
  2. Abbreviations: LPA lysophosphatidic acid, cLPA cyclic lysophosphatidic acid, aLPA alkyl-Lysophosphatidic acid, SE standard error, FDR false discovery rate