Neurofilament light chain in the vitreous humor of the eye

Table 4 Eye and systemic disease and NfL levels

*Predictor*	*Beta*	SE	t	*p value*
Macular degeneration	− 1.06	1.38	− 0.77	0.44
Diabetic retinopathy (DR)	0.45	0.61	0.74	0.46
Age-related cataract (ARC)	1.21	1.01	1.19	0.24
ARC + DR	0.22	0.61	0.36	0.72
Cataract surgery	− 0.32	0.68	− 0.47	0.64
Glaucoma	− 0.61	0.90	− 0.68	0.50
Epiretinal membrane	− 1.20	0.74	− 1.62	0.11
Retinal detachment	− 0.29	0.67	− 0.43	0.67
Macular hole	− 0.15	0.84	− 0.17	0.86
Proliferative diabetic retinopathy (stage 4 DR vs. no DR)	0.45	0.62	0.73	0.47
Hypertension	0.28	0.70	0.40	0.69
Diabetes	0.62	0.61	1.01	0.31
Hyperlipidemia	− 0.034	0.63	− 0.05	0.96

No significant association was found between vitreous NfL and the various ophthalmic and systemic diseases in this patient population (p > 0.05)

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