Alzheimer's Research & Therapy

Table 1 Significance levels (adjusted p values) of the markers compared amongst groups

From: Amyloid-β_1–43 cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations

	*Pathogenic* vs *controls*			*VUS* vs *controls*			*p.E318G* vs *controls*
	Est.	St.	p value	Est.	St.	p value	Est.	St.	p value
Aβ_1–43	39.93	2.90	0.037	37.36	4.15	< 0.001	45.43	5.99	< 0.001
Aβ_1–43/Aβ_1–40	42.92	3.12	0.018	40.08	4.45	< 0.001	46.97	6.20	< 0.001
Aβ_1–43/Aβ_1–42	28.45	2.07	0.384	37.37	4.15	< 0.001	44.85	5.91	< 0.001
Aβ_1–42	40.32	2.93	0.033	32.33	3.59	0.003	41.42	5.46	< 0.001
Aβ_1–42/Aβ_1–40	43.52	3.14	0.015	33.59	3.73	0.002	43.87	5.79	< 0.001
sAPPα	12.54	0.91	1.0	31.04	3.45	0.006	26.90	3.55	0.004
sAPPβ	14.06	1.02	1.0	31.32	3.48	0.005	21.87	2.89	0.039
Aβ_1–43/sAPPα	37.44	2.73	0.064	21.18	2.35	0.186	38.79	5.12	< 0.001
Aβ_1–43/sAPPβ	36.31	2.64	0.082	21.49	2.39	0.169	41.25	5.44	< 0.001

Kruskal-Wallis was performed to assess differences amongst groups. Significance level p < 0.05 (adjusted p values). Abbreviations: Est. test estimate, St. standard test statistic

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ISSN: 1758-9193

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