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Table 1 Significance levels (adjusted p values) of the markers compared amongst groups

From: Amyloid-β1–43 cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations

  Pathogenic vs controls VUS vs controls p.E318G vs controls
Est. St. p value Est. St. p value Est. St. p value
1–43 39.93 2.90 0.037 37.36 4.15 < 0.001 45.43 5.99 < 0.001
1–43/Aβ1–40 42.92 3.12 0.018 40.08 4.45 < 0.001 46.97 6.20 < 0.001
1–43/Aβ1–42 28.45 2.07 0.384 37.37 4.15 < 0.001 44.85 5.91 < 0.001
1–42 40.32 2.93 0.033 32.33 3.59 0.003 41.42 5.46 < 0.001
1–42/Aβ1–40 43.52 3.14 0.015 33.59 3.73 0.002 43.87 5.79 < 0.001
sAPPα 12.54 0.91 1.0 31.04 3.45 0.006 26.90 3.55 0.004
sAPPβ 14.06 1.02 1.0 31.32 3.48 0.005 21.87 2.89 0.039
1–43/sAPPα 37.44 2.73 0.064 21.18 2.35 0.186 38.79 5.12 < 0.001
1–43/sAPPβ 36.31 2.64 0.082 21.49 2.39 0.169 41.25 5.44 < 0.001
  1. Kruskal-Wallis was performed to assess differences amongst groups. Significance level p < 0.05 (adjusted p values). Abbreviations: Est. test estimate, St. standard test statistic