From: Association of carotid and intracranial stenosis with Alzheimer’s disease biomarkers
AD biomarker | Variables | Presence of any detectable stenosis | |||||||
Any extracranial carotid stenosis | Any intracranial stenosis | ||||||||
Stenosis− | Stenosis+ | p value | da | Stenosis− | Stenosis+ | p value | d | ||
Aβ biomarker | Global Aβ | 1.627 ± 0.530 | 1.609 ± 0.412 | 0.857 | 0.334 | 1.648 ± 0.539 | 1.573 ± 0.472 | 0.304 | 0.147 |
Neurodegeneration biomarker | AD-CT | 2.600 ± 0.284 | 2.518 ± 0.260 | 0.205 | 0.288 | 2.596 ± 0.311 | 2.561 ± 0.234 | 0.376 | 0.121 |
HVa | − 2064 ± 1225 | − 2396 ± 947 | 0.146 | 0.277 | − 2004 ± 1262 | − 2362 ± 1109 | 0.047* | 0.296 | |
Presence of stenosis based on severity threshold | |||||||||
≥ 50% intracranial stenosisb | Number of stenotic intracranial arteries ≥ 2c | ||||||||
Stenosis− | Stenosis+ | p value | d | Stenosis− | Stenosis+ | p value | d | ||
Aβ biomarker | Global Aβ | 1.646 ± 0.522 | 1.415 ± 0.411 | 0.052 | 0.451 | 1.640 ± 0.536 | 1.544 ± 0.414 | 0.234 | 0.185 |
Neurodegeneration biomarker | AD-CT | 2.584 ± 0.290 | 2.579 ± 0.254 | 0.940 | 0.017 | 2.598 ± 0.292 | 2.521 ± 0.252 | 0.136 | 0.270 |
HVa | − 2087 ± 1202 | − 2515 ± 1327 | 0.128 | 0.352 | − 2021 ± 1227 | − 2602 ± 1080 | 0.008* | 0.484 | |
Presence of stenosis according to location | |||||||||
Anterior circulation | Posterior circulation | ||||||||
Stenosis− | Stenosis+ | p value | d | Stenosis− | Stenosis+ | p value | d | ||
Aβ biomarker | Global Aβ | 1.667 ± 0.535 | 1.519 ± 0.456 | 0.049* | 0.288 | 1.623 ± 0.519 | 1.605 ± 0.498 | 0.878 | 0.035 |
Neurodegeneration biomarker | AD-CT | 2.585 ± 0.309 | 2.580 ± 0.224 | 0.902 | 0.017 | 2.589 ± 0.289 | 2.540 ± 0.257 | 0.459 | 0.171 |
HVa | − 2047 ± 1244 | − 2323 ± 1147 | 0.142 | 0.227 | − 2100 ± 1217 | − 2400 ± 1236 | 0.287 | 0.246 |