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Table 2 Vessel stenosis features and AD biomarkers of participants

From: Association of carotid and intracranial stenosis with Alzheimer’s disease biomarkers

Variables CN (N = 281) CI (N = 199) p value
Large vessel stenosis
 Presence of any detectable stenosis
  Any extracranial carotid stenosis 23 (8.2%) 22 (11.2%)a 0.264
  Any intracranial stenosis 77 (27.4%) 71 (35.7%) 0.053
  Both extracranial carotid and intracranial stenosis 12 (4.3%) 10 (5.0%) 0.697
 Presence of stenosis based on severity threshold
  ≥ 50% intracranial stenosis 19 (6.8%) 21 (10.6%) 0.139
  Number of stenotic intracranial arteries ≥ 2 44 (15.7%) 38 (19.1%) 0.324
 Presence of stenosis according to location
  Anterior circulation stenosis 69 (24.6%) 61 (30.7%) 0.139
  Posterior circulation stenosis 21 (7.5%) 21 (10.6%) 0.239
AD biomarkers
 Global Aβ deposition (SUVR) 1.184 ± 0.239 1.621 ± 0.156 < 0.001*
 Aβ positivity 39 (13.9%) 112 (56.3%) < 0.001*
 Neurodegeneration biomarkers
  AD-CT (mm) 2.866 ± 0.174 2.584 ± 0.286 < 0.001*
  HVa (mm3) − 759 ± 838 − 2132 ± 1219 < 0.001*
  1. Data are presented as mean ± SD or n (%)
  2. CN cognitively normal, CI cognitively impaired, AD-CT Alzheimer’s disease-signature cortical thickness, HVa hippocampal volume adjusted for intracranial volume
  3. aAmong CI group, data for 196 individuals were available
  4. *p < 0.05