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Table 2 Vessel stenosis features and AD biomarkers of participants

From: Association of carotid and intracranial stenosis with Alzheimer’s disease biomarkers

Variables

CN (N = 281)

CI (N = 199)

p value

Large vessel stenosis

 Presence of any detectable stenosis

  Any extracranial carotid stenosis

23 (8.2%)

22 (11.2%)a

0.264

  Any intracranial stenosis

77 (27.4%)

71 (35.7%)

0.053

  Both extracranial carotid and intracranial stenosis

12 (4.3%)

10 (5.0%)

0.697

 Presence of stenosis based on severity threshold

  ≥ 50% intracranial stenosis

19 (6.8%)

21 (10.6%)

0.139

  Number of stenotic intracranial arteries ≥ 2

44 (15.7%)

38 (19.1%)

0.324

 Presence of stenosis according to location

  Anterior circulation stenosis

69 (24.6%)

61 (30.7%)

0.139

  Posterior circulation stenosis

21 (7.5%)

21 (10.6%)

0.239

AD biomarkers

 Global Aβ deposition (SUVR)

1.184 ± 0.239

1.621 ± 0.156

< 0.001*

 Aβ positivity

39 (13.9%)

112 (56.3%)

< 0.001*

 Neurodegeneration biomarkers

  AD-CT (mm)

2.866 ± 0.174

2.584 ± 0.286

< 0.001*

  HVa (mm3)

− 759 ± 838

− 2132 ± 1219

< 0.001*

  1. Data are presented as mean ± SD or n (%)
  2. CN cognitively normal, CI cognitively impaired, AD-CT Alzheimer’s disease-signature cortical thickness, HVa hippocampal volume adjusted for intracranial volume
  3. aAmong CI group, data for 196 individuals were available
  4. *p < 0.05