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Table 3 Top-ranked genes based on the combined GWAS and network score. Genes are listed only if the phenotype induced by knockdown in flies is AD-related based on evidence of defective memory (DM), defective aging (DA), oxidative stress (OS), or premature aging

From: Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

Gene name Phenotype One-tailed Z-score p value
GWAS Network Combined Unadjusted FDR
EPS8 DM 3.16 2.78 4.20 1.34E−05 8.77E−03
HSPA2 DA 2.98 1.51 3.17 7.51E−04 2.45E−01
ADAM10 DA 2.61 1.50 2.90 1.84E−03 4.01E−01
HSPA6 DA 2.13 1.63 2.66 3.88E−03 6.34E−01
CAMK2A DM 0.94 2.60 2.50 6.13E−03 7.91E−01
HDAC1 DA, OS 1.40 1.97 2.38 8.55E−03 7.91E−01
MAPK10 DA, OS 1.58 1.68 2.30 1.06E−02 7.91E−01
CAT DA, OS 2.31 0.89 2.27 1.17E−02 7.91E−01
FXR1 DM 0.58 2.60 2.24 1.24E−02 7.91E−01
CD164 DM 0.90 2.23 2.21 1.34E−02 7.91E−01
HSPB1 OS 1.58 1.52 2.19 1.43E−02 7.91E−01
FBXW7 OS 0.66 2.34 2.12 1.69E−02 7.91E−01
DAGLB OS 1.52 1.48 2.12 1.71E−02 7.91E−01
NFE2L3 OS 1.71 1.20 2.06 1.98E−02 7.91E−01
MAFB OS 1.56 1.31 2.03 2.11E−02 7.91E−01
ITGAX DM 1.67 1.20 2.03 2.11E−02 7.91E−01
SETBP1 DA 1.26 1.60 2.02 2.14E−02 7.91E−01
ACHE DM 2.12 0.71 2.00 2.28E−02 7.91E−01
ITGAM DM 1.56 1.19 1.94 2.59E−02 7.91E−01
ITPR1 DA 1.01 1.72 1.93 2.68E−02 7.91E−01
HBB OS 2.68 0.02 1.91 2.81E−02 7.91E−01
PLK3 DA 2.16 0.50 1.88 2.98E−02 7.91E−01
TRIB3 DM 1.35 1.29 1.87 3.08E−02 7.91E−01
RCAN1 DA, DM, OS 1.24 1.40 1.87 3.10E−02 7.91E−01
GABARAP DM 0.74 1.87 1.85 3.23E−02 7.91E−01
NIPBL DM 0.72 1.90 1.85 3.24E−02 7.91E−01
GPD1 OS 1.54 1.06 1.84 3.26E−02 7.91E−01
GRIN2A DM 0.98 1.59 1.82 3.47E−02 8.10E−01
ITPKA OS 0.57 1.95 1.78 3.78E−02 8.29E−01
DNM1 DM 1.02 1.46 1.76 3.94E−02 8.29E−01
PGC DA 1.28 1.19 1.75 4.00E−02 8.29E−01
CIDEC DM 1.60 0.87 1.74 4.06E−02 8.29E−01
TXNRD2 DA 1.85 0.59 1.73 4.21E−02 8.34E−01
BZW2 DM 1.60 0.80 1.69 4.51E−02 8.67E−01
CBX3 DA 1.54 0.81 1.66 4.81E−02 8.91E−01
PCNA OS 2.31 0.03 1.65 4.91E−02 8.91E−01