Table 3 Top-ranked genes based on the combined GWAS and network score. Genes are listed only if the phenotype induced by knockdown in flies is AD-related based on evidence of defective memory (DM), defective aging (DA), oxidative stress (OS), or premature aging

EPS8

DM

3.16

2.78

4.20

1.34E−05

8.77E−03

HSPA2

DA

2.98

1.51

3.17

7.51E−04

2.45E−01

ADAM10

DA

2.61

1.50

2.90

1.84E−03

4.01E−01

HSPA6

DA

2.13

1.63

2.66

3.88E−03

6.34E−01

CAMK2A

DM

0.94

2.60

2.50

6.13E−03

7.91E−01

HDAC1

DA, OS

1.40

1.97

2.38

8.55E−03

7.91E−01

MAPK10

DA, OS

1.58

1.68

2.30

1.06E−02

7.91E−01

CAT

DA, OS

2.31

0.89

2.27

1.17E−02

7.91E−01

FXR1

DM

0.58

2.60

2.24

1.24E−02

7.91E−01

CD164

DM

0.90

2.23

2.21

1.34E−02

7.91E−01

HSPB1

OS

1.58

1.52

2.19

1.43E−02

7.91E−01

FBXW7

OS

0.66

2.34

2.12

1.69E−02

7.91E−01

DAGLB

OS

1.52

1.48

2.12

1.71E−02

7.91E−01

NFE2L3

OS

1.71

1.20

2.06

1.98E−02

7.91E−01

MAFB

OS

1.56

1.31

2.03

2.11E−02

7.91E−01

ITGAX

DM

1.67

1.20

2.03

2.11E−02

7.91E−01

SETBP1

DA

1.26

1.60

2.02

2.14E−02

7.91E−01

ACHE

DM

2.12

0.71

2.00

2.28E−02

7.91E−01

ITGAM

DM

1.56

1.19

1.94

2.59E−02

7.91E−01

ITPR1

DA

1.01

1.72

1.93

2.68E−02

7.91E−01

HBB

OS

2.68

0.02

1.91

2.81E−02

7.91E−01

PLK3

DA

2.16

0.50

1.88

2.98E−02

7.91E−01

TRIB3

DM

1.35

1.29

1.87

3.08E−02

7.91E−01

RCAN1

DA, DM, OS

1.24

1.40

1.87

3.10E−02

7.91E−01

GABARAP

DM

0.74

1.87

1.85

3.23E−02

7.91E−01

NIPBL

DM

0.72

1.90

1.85

3.24E−02

7.91E−01

GPD1

OS

1.54

1.06

1.84

3.26E−02

7.91E−01

GRIN2A

DM

0.98

1.59

1.82

3.47E−02

8.10E−01

ITPKA

OS

0.57

1.95

1.78

3.78E−02

8.29E−01

DNM1

DM

1.02

1.46

1.76

3.94E−02

8.29E−01

PGC

DA

1.28

1.19

1.75

4.00E−02

8.29E−01

CIDEC

DM

1.60

0.87

1.74

4.06E−02

8.29E−01

TXNRD2

DA

1.85

0.59

1.73

4.21E−02

8.34E−01

BZW2

DM

1.60

0.80

1.69

4.51E−02

8.67E−01

CBX3

DA

1.54

0.81

1.66

4.81E−02

8.91E−01

PCNA

OS

2.31

0.03

1.65

4.91E−02

8.91E−01