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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

Fig. 2

Expression of RAD genes is region-specific. Heatmap shows the expression patterns in the brain high-level structures (hst) and mid-level structures (mst) for 20 RAD genes including 10 of the most well-established AD genes (i.e., APOE, APP, PSEN1, PSEN2, CR1, BIN1, SORL1, ABCA7, MAPT, TREM2) and 10 others chosen randomly from the total set of 52 RAD genes in Table 1. Patterns for the other 32 genes were similar but not shown to improve visualization. The strength and pattern of the expression are color-coded according to the scheme shown on the right of the heatmap with red indicating increased expression and blue indicating decreased expression. BS, brain stem; CB, cerebellum; CX, cerebrum; Amg, amygdala; BF, basal forebrain; Bpons, basis pontis; CbCx, cerebellar cortex; CbN, cerebellar nucleus; CgG, central gray, gamma; CI, claustrum; DT, dentate nucleus; ET, epithalamus; FL, frontal lobe; GP, globus pallidus; HiF, hippocampal fissure; Hy, hypothalamus; Ins, insula; MES, mesencephalon; MY, myelencephalon; OL, occipital lobe; PHG, parahippocampal gyrus; PL, paralemniscal nucleus; PTg, pedunculotegmental nucleus; SbT, subthalamus; Str, subiculum, transition area; TL, temporal lobe; VT, ventral tegmental area

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