T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

Table 1 Participant demographics

	Group
	HC	MCI	AD	Total
N (male to female)	97 (46:51)	49 (27:22)	10 (2:8)	156 (75:81)
Age (years)	69.3 ± 8.58	72.2 ± 9.03	77.9 ± 9.94	70.7 ± 9.05
YOE	15.8 ± 3.16	14.2 ± 2.81	13.1 ± 2.60	15.1 ± 3.13
Cognitive score (normalised to HC)	0.00 ± 1.00	− 4.08 ± 2.09	− 8.50 ± 3.15	− 1.83 ± 3.02

Data show mean ± standard deviation, combined for studies 1 and 2. Cognitive score is calculated as a Z score relative to the healthy control group of each study, separately, as different cognitive tests were used (study 1: MoCA; study 2: ACE-III). For this reason, the HC group by definition has a mean ± SD of 0 ± 1. HC healthy control, MCI mild cognitive impairment, AD Alzheimer’s disease, YOE years of education

ISSN: 1758-9193