White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

Table 4 Association between WMH, Aβ, and executive functions

		Total			Frontal			Parietal			Temporal			Occipital			Corpus callosum
		β	p	R²	β	p	R²	β	p	R²	β	p	R²	β	p	R²	β	p	R²
Model A	WMH	− 0.23	0.048	0.30	− 0.25	0.02	0.31	− 0.20	0.09	0.29	− 0.06	1.00	0.27	− 0.22	0.05	0.30	− 0.20	0.08	0.29
Model B	WMH	− 0.32	0.01	0.30	− 0.33	0.00	0.31	− 0.28	0.02	0.29	− 0.15	0.62	0.25	− 0.32	0.01	0.31	− 0.26	0.04	0.28
Model B	Aβ	0.06	1.00	0.30	0.05	1.00	0.31	0.07	1.00	0.29	0.10	1.00	0.25	0.09	1.00	0.31	0.06	1.00	0.28
Model C	WMH × Aβ	− 0.07	1.00	0.30	0.61	1.00	0.31	− 0.15	1.00	0.29	− 0.14	1.00	0.24	− 0.70	1.00	0.31	0.45	1.00	0.28

Standardized betas (β), corrected p values, and adjusted R² values are reported from regression models where composite scores of executive functions are regressed onto WMH (model A), WMH and Aβ (model B), and the interaction between WMH and Aβ (model C). All models are controlled for age, sex, level of education, and TIV. Significant p values (< 0.05) after applying Bonferroni correction (accounting for multiple testing across the 4 cognitive domains) are in bold. Analyses were performed with 136 participants in model A and with 109 participants in models B and C
WMH white matter hyperintensities, Aβ cortical β-amyloid

ISSN: 1758-9193