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Table 3 Relationships between total WMH, age, vascular risk factors, and Aβ in the subgroup of young/middle-aged adults (A) and in the subgroup of older adults (B)

From: White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

(A) Total WMH (B) Total WMH
Model 1 Model 2 Model 1 Model 2
β p β p R2 β p β p R2
Age 0.47 < 0.001 0.35 0.01 0.32 Age 0.53 < 0.001 0.42 0.01 0.26
Sex − 0.05 0.72 Sex − 0.03 0.89
SBP 0.24 0.02 0.01 0.96 SBP 0.35 0.02 0.10 0.51
DBP 0.37 < 0.001 0.23 0.10 DBP 0.19 0.19
HbA1C 0.20 0.06 HbA1C 0.39 0.01 0.20 0.17
0.24 0.05 0.09 0.39 − 0.23 0.14
  1. Standardized betas (β) and p values are reported from regression models where total WMH (log-transformed) are regressed onto age, sex, SBP, DBP, HbA1C, and Aβ controlling for TIV (model 1), or for TIV and significant covariates (model 2) in young/middle-aged adults (A; N = 86, mean age 37.41 ± 12.85) and in older adults (B, N = 51, mean age 71.20 ± 6.26). Adjusted R2 were indicated for model 2. Significant p values (< 0.05) are in bold
  2. For young/middle-aged adults, analyses were performed with 86 participants for age and sex, 85 participants for SBP and DBP, 80 participants for HbA1C, and 65 participants for Aβ in model 1 and with 65 participants in model 2. For older adults, analyses were performed with 51 participants for age and sex; 48 participants for SBP, DBP, and HbA1C; and 44 participants for Aβ in model 1 and with 45 participants in model 2
  3. SBP systolic blood pressure, DBP diastolic blood pressure, HbA1C glycated hemoglobin, cortical β-amyloid, TIV total intracranial volume