Alzheimer's Research & Therapy

Table 2 Relationships between WMH, age, vascular risk factors, and Aβ

From: White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

	Total WMH					Frontal WMH					Parietal WMH
	Model 1		Model 2			Model 1		Model 2			Model 1		Model 2
	β	p	β	p	R²	β	p	β	p	R²	β	p	β	p	R²
Age	0.80	< 0.001	0.73	< 0.001	0.66	0.81	< 0.001	0.79	< 0.001	0.69	0.80	< 0.001	0.77	< 0.001	0.69
Sex	0.00	0.99	–	–		− 0.01	0.90	–	–		0.10	0.41	–	–
SBP	0.51	< 0.001	0.13	0.10		0.51	< 0.001	0.12	0.17		0.55	< 0.001	0.22	< 0.01
DBP	0.41	< 0.001	− 0.02	0.78		0.41	< 0.001	− 0.05	0.56		0.40	< 0.001	− 0.11	0.13
HbA1C	0.52	< 0.001	0.00	0.95		0.53	< 0.001	0.02	0.81		0.51	< 0.001	− 0.03	0.61
Aβ	0.19	0.05	–	–		0.19	0.04	− 0.02	0.68		0.09	0.34	–	–
	Temporal WMH					Occipital WMH					Callosal WMH
	Model 1		Model 2			Model 1		Model 2			Model 1		Model 2
	β	p	β	p	R²	β	p	β	p	R²	β	p	β	p	R²
Age	0.83	< 0.001	0.79	< 0.001	0.71	0.69	< 0.001	0.58	< 0.001	0.51	0.77	< 0.001	0.74	< 0.001	0.61
Sex	0.04	0.73	–	–		0.12	0.32	–	–		− 0.07	0.58	–	–
SBP	0.48	< 0.001	0.07	0.38		0.47	< 0.001	0.20	0.07		0.51	< 0.001	0.14	0.11
DBP	0.37	< 0.001	− 0.06	0.43		0.30	< 0.001	− 0.10	0.31		0.40	< 0.001	− 0.03	0.75
HbA1C	0.55	< 0.001	0.07	0.33		0.48	< 0.001	0.07	0.43		0.48	< 0.001	− 0.04	0.58
Aβ	0.23	0.02	0.00	0.97		0.20	0.04	0.05	0.48		0.15	0.11	–	–

Standardized betas (β) and p values are reported from regression models where total and regional WMH (log-transformed) are regressed onto age, sex, SBP, DBP, HbA1C, and Aβ controlling for TIV (model 1) or TIV and significant covariates (model 2). Adjusted R² values were indicated for model 2. Significant p values (< 0.05) are in bold
Analyses were performed with 137 participants for age and sex, 133 participants for SBP and DBP, 128 participants for HbA1C, and 109 participants for Aβ in model 1. Analyses were performed with 125 participants (for total, parietal, and callosal WMH) and 99 participants when Aβ was included (for frontal, temporal, and occipital WMH) in model 2. SBP systolic blood pressure, DBP diastolic blood pressure, HbA1C glycated hemoglobin, Aβ cortical β-amyloid, TIV total intracranial volume

Back to article page

ISSN: 1758-9193

Contact us

General enquiries: journalsubmissions@springernature.com