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Table 2 Relationships between WMH, age, vascular risk factors, and Aβ

From: White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

  Total WMH Frontal WMH Parietal WMH
Model 1 Model 2 Model 1 Model 2 Model 1 Model 2
β p β p R2 β p β p R2 β p β p R2
Age 0.80 < 0.001 0.73 < 0.001 0.66 0.81 < 0.001 0.79 < 0.001 0.69 0.80 < 0.001 0.77 < 0.001 0.69
Sex 0.00 0.99 − 0.01 0.90 0.10 0.41
SBP 0.51 < 0.001 0.13 0.10 0.51 < 0.001 0.12 0.17 0.55 < 0.001 0.22 < 0.01
DBP 0.41 < 0.001 − 0.02 0.78 0.41 < 0.001 − 0.05 0.56 0.40 < 0.001 − 0.11 0.13
HbA1C 0.52 < 0.001 0.00 0.95 0.53 < 0.001 0.02 0.81 0.51 < 0.001 − 0.03 0.61
0.19 0.05 0.19 0.04 − 0.02 0.68 0.09 0.34
  Temporal WMH Occipital WMH Callosal WMH
Model 1 Model 2 Model 1 Model 2 Model 1 Model 2
β p β p R2 β p β p R2 β p β p R2
Age 0.83 < 0.001 0.79 < 0.001 0.71 0.69 < 0.001 0.58 < 0.001 0.51 0.77 < 0.001 0.74 < 0.001 0.61
Sex 0.04 0.73 0.12 0.32 − 0.07 0.58
SBP 0.48 < 0.001 0.07 0.38 0.47 < 0.001 0.20 0.07 0.51 < 0.001 0.14 0.11
DBP 0.37 < 0.001 − 0.06 0.43 0.30 < 0.001 − 0.10 0.31 0.40 < 0.001 − 0.03 0.75
HbA1C 0.55 < 0.001 0.07 0.33 0.48 < 0.001 0.07 0.43 0.48 < 0.001 − 0.04 0.58
0.23 0.02 0.00 0.97 0.20 0.04 0.05 0.48 0.15 0.11
  1. Standardized betas (β) and p values are reported from regression models where total and regional WMH (log-transformed) are regressed onto age, sex, SBP, DBP, HbA1C, and Aβ controlling for TIV (model 1) or TIV and significant covariates (model 2). Adjusted R2 values were indicated for model 2. Significant p values (< 0.05) are in bold
  2. Analyses were performed with 137 participants for age and sex, 133 participants for SBP and DBP, 128 participants for HbA1C, and 109 participants for Aβ in model 1. Analyses were performed with 125 participants (for total, parietal, and callosal WMH) and 99 participants when Aβ was included (for frontal, temporal, and occipital WMH) in model 2. SBP systolic blood pressure, DBP diastolic blood pressure, HbA1C glycated hemoglobin, cortical β-amyloid, TIV total intracranial volume