Fig. 5
From: The two faces of synaptic failure in AppNL-G-F knock-in mice
Analysis of action potential-independent mEPSCs (a–c) and mIPSCs (d–f) in 6–8 months old AppNL and AppNL-G-F mice. a, b The mean frequency but not the amplitude of mEPSCs is markedly increased in AppNL-G-F mice as compared to AppNL control animals (see insets in a and b, p = 0.0012 Welch test). c Representative traces from mEPSC recordings illustrate the higher mEPSC frequency of CA1 pyramidal neurons from AppNL-G-F mice compared to AppNL controls. d mEPSC half-width, a measure that characterizes the kinetics of inactivation, is unchanged in AppNL-G-F mice. Analyses of the probability distributions of the data (a, b, d) revealed significant genotype differences for all three parameters. e, f Both mean amplitude and mean frequency of mIPSCs show a pronounced increase in AppNL-G-F mice [amplitude AppNL-G-F (inset in e, p = 0.0003 Welch test), frequency (inset in f, p = 0.0013 Welch test)]. g Representative traces from mIPSC recordings illustrate the marked increase in the mIPSC frequency of CA1 pyramidal neurons from AppNL-G-F mice compared to AppNL controls. h The kinetics of inactivation as measured by the half-width of mIPSCs was the same in both genotypes. Kolmogorov-Smirnov tests yielded significant genotype differences for the amplitude, the frequency, and the half-width of mIPSCs. Asterisks indicate difference between AppNL and AppNL-G-F: **p < 0.01, ***p < 0.001