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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: The two faces of synaptic failure in AppNL-G-F knock-in mice

Fig. 2

Unchanged basal synaptic transmission, short-term plasticity, and long-term plasticity in the hippocampal CA1 region of AppNL and AppNL-G-F mice at 3–4 months of age. a I/O curves of AppNL and AppNL-G-F mice were almost identical. b Paired-pulse ratio was intact at every interval tested in both groups. c AppNL and AppNL-G-F animals developed a robust LTP for 4 h. d Triple repetition of LFS stimulation induced robust LTD that did not differ between AppNL and AppNL-G-F mice. Data are shown as mean ± SEM

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