Fig. 5

Associations between baseline Aβ PET, CSF pTau/Aβ₄₀, tau PET and longitudinal tau PET change. Associations between annual temporal tau PET change (ΔFTP SUVR in Temporal-metaROI) and a baseline Aβ PET, b CSF pTau/Aβ₄₀, and c Temporal-metaROI tau PET (FTP SUVR in Temporal-metaROI). d All the possible pathways between Aβ PET, CSF pTau/Aβ₄₀, FTP, and ΔFTP were calculated in a serial mediation model in Aβ+ participants. Aβ PET, CSF pTau/Aβ₄₀, FTP, and ΔFTP were converted to standard z scores. Total, direct, and indirect associations were calculated via a 5000-iteration bootstrapping procedure. Abbreviations: Aβ = amyloid-β; FTP = ¹⁸F-flortaucipir; pTau = phosphorylated tau; SUVR = standardized uptake value ratio