Fig. 3From: Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s diseaseThe sAPPα and sAPPβ variants remain unaltered in the AD frontal cortex. Representative western blots of human frontal cortex samples from NDC (closed symbol; n = 7) and AD subjects (open symbol; n = 7) probed with antibodies against sAPPα (a) or sAPPβ (b). The densitometric quantifications of the species attributed to the APP-695 and APP-KPI variants (see Fig. 1c) are shown, with equivalent amounts of protein loaded in each lane and using vinculin as a loading control. Calculations were performed in duplicate. c Graph of the quotients obtained by dividing the values for the sAPP species (sAPPα or sAPPβ) derived from the APP-KPI variant by those derived from APP695 for each sample. None of the comparisons resulted in statistically significant differences between the AD and NDC samplesBack to article page