Skip to main content
Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s disease

Fig. 1

Increased APP mRNA in the frontal cortex of AD patients. Relative mRNA expression of transcripts for a total APP, and the b APP-KPI and APP-695 splice variants, analyzed by qRT-PCR in frontal cortex tissue from NDC (n = 7) and AD subjects (Braak stages V–VI, – = 7). To analyze APP transcripts, specific Power SYBR® Green PCR Master Mix primers were employed and the specificity of the PCR products was confirmed by analyzing the dissociation curves. Transcript levels were calculated by the comparative 2−ΔCt method with respect to 18S rRNA from the same cDNA and expressed as the mean ± SEM: p < 0.001 relative to the NDCs as indicated

Back to article page