|
Risk factors
|
Without dementia
|
Incident dementia
|
χ2 test
|
Death (competing event)
|
Dementia
|
|---|
|
N = 989
|
N = 111
|
P value
|
SHR (95% CI)
|
P value
|
SHR (95% CI)
|
P value
|
|---|
|
Non-modifiable
|
|
Age (class 1935–37)
|
522 (52.7)
|
69 (62.2)
|
0.060
|
1.21 (0.82–1.78)
|
0.332
|
1.20 (0.82–1.78)
|
0.347
|
|
Sex (female)
|
534 (54.0)
|
55 (49.5)
|
0.373
|
0.76 (0.53–1.11)
|
0.156
|
0.82 (0.56–1.19)
|
0.287
|
|
APOE ε4
|
166 (16.8)
|
34 (30.6)
|
< 0.001
|
0.92 (0.47–12.16)
|
0.742
|
2.00 (1.34–3.01)
|
0.001
|
|
Modifiable
|
|
Low education
|
548 (55.4)
|
69 (62.2)
|
0.174
|
1.15 (0.79–1.68)
|
0.459
|
1.38 (0.94–2.03)
|
0.103
|
|
Obesity
|
259 (27.3)
|
29 (27.9)
|
0.908
|
0.68 (0.42–1.09)
|
0.107
|
1.08 (0.70–1.66)
|
0.716
|
|
Hypertension
|
685 (69.4)
|
81 (73.6)
|
0.359
|
1.08 (0.72–1.63)
|
0.697
|
1.27 (0.83–1.94)
|
0.270
|
|
Diabetes
|
198 (20.2)
|
31 (28.2)
|
0.053
|
1.30 (0.84–12.96)
|
0.200
|
1.55 (1.02–2.36)
|
0.042
|
|
Depression
|
51 (5.2)
|
5 (4.5)
|
0.767
|
2.11 (1.07–4.16)
|
0.032
|
0.99 (0.40–2.45)
|
0.984
|
|
Smoking
|
86 (8.7)
|
11 (9.9)
|
0.669
|
2.04 (1.24–3.37)
|
0.005
|
1.12 (0.60–2.09)
|
0.715
|
|
Physical inactivity
|
462 (46.8)
|
60 (54.1)
|
0.145
|
1.27 (0.88–1.84)
|
0.203
|
1.42 (0.98–2.06)
|
0.064
|
|
Hearing loss
|
123 (12.5)
|
16 (14.5)
|
0.539
|
1.07 (0.62–1.83)
|
0.803
|
1.20 (0.71–2.02)
|
0.493
|
|
Loneliness
|
117 (11.9)
|
10 (9.1)
|
0.388
|
1.31 (0.77–2.21)
|
0.316
|
0.82 (0.42–1.59)
|
0.562
|
|
Heart disease
|
255 (25.8)
|
42 (37.8)
|
0.007
|
1.29 (0.87–1.91)
|
0.206
|
1.61 (1.09–2.37)
|
0.016
|
|
Stroke
|
64 (6.5)
|
20 (18.2)
|
< 0.001
|
2.05 (1.18–3.55)
|
0.011
|
2.69 (1.67–4.35)
|
< 0.001
|
|
Head injury
|
77 (7.8)
|
7 (6.3)
|
0.576
|
1.12 (0.55–2.24)
|
0.757
|
0.84 (0.39–1.80)
|
0.649
|
|
Delirium
|
5 (0.5)
|
7 (6.4)
|
< 0.001
|
1.52 (0.37–6.28)
|
0.562
|
8.52 (3.62–20.05)
|
< 0.001
|
- Values represent counts (percentage)
- SHR sub-hazard ratio
