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Table 2 Descriptive variables and impact of each factor on dementia incidence across 8 years, based on univariable models, with death as a competing event

From: Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study

Risk factors Without dementia Incident dementia χ2 test Death (competing event) Dementia
N = 989 N = 111 P value SHR (95% CI) P value SHR (95% CI) P value
Non-modifiable
 Age (class 1935–37) 522 (52.7) 69 (62.2) 0.060 1.21 (0.82–1.78) 0.332 1.20 (0.82–1.78) 0.347
 Sex (female) 534 (54.0) 55 (49.5) 0.373 0.76 (0.53–1.11) 0.156 0.82 (0.56–1.19) 0.287
 APOE ε4 166 (16.8) 34 (30.6) < 0.001 0.92 (0.47–12.16) 0.742 2.00 (1.34–3.01) 0.001
Modifiable
 Low education 548 (55.4) 69 (62.2) 0.174 1.15 (0.79–1.68) 0.459 1.38 (0.94–2.03) 0.103
 Obesity 259 (27.3) 29 (27.9) 0.908 0.68 (0.42–1.09) 0.107 1.08 (0.70–1.66) 0.716
 Hypertension 685 (69.4) 81 (73.6) 0.359 1.08 (0.72–1.63) 0.697 1.27 (0.83–1.94) 0.270
 Diabetes 198 (20.2) 31 (28.2) 0.053 1.30 (0.84–12.96) 0.200 1.55 (1.02–2.36) 0.042
 Depression 51 (5.2) 5 (4.5) 0.767 2.11 (1.07–4.16) 0.032 0.99 (0.40–2.45) 0.984
 Smoking 86 (8.7) 11 (9.9) 0.669 2.04 (1.24–3.37) 0.005 1.12 (0.60–2.09) 0.715
 Physical inactivity 462 (46.8) 60 (54.1) 0.145 1.27 (0.88–1.84) 0.203 1.42 (0.98–2.06) 0.064
 Hearing loss 123 (12.5) 16 (14.5) 0.539 1.07 (0.62–1.83) 0.803 1.20 (0.71–2.02) 0.493
 Loneliness 117 (11.9) 10 (9.1) 0.388 1.31 (0.77–2.21) 0.316 0.82 (0.42–1.59) 0.562
 Heart disease 255 (25.8) 42 (37.8) 0.007 1.29 (0.87–1.91) 0.206 1.61 (1.09–2.37) 0.016
 Stroke 64 (6.5) 20 (18.2) < 0.001 2.05 (1.18–3.55) 0.011 2.69 (1.67–4.35) < 0.001
 Head injury 77 (7.8) 7 (6.3) 0.576 1.12 (0.55–2.24) 0.757 0.84 (0.39–1.80) 0.649
 Delirium 5 (0.5) 7 (6.4) < 0.001 1.52 (0.37–6.28) 0.562 8.52 (3.62–20.05) < 0.001
  1. Values represent counts (percentage)
  2. SHR sub-hazard ratio